急性冠状动脉综合征患者戒烟前后的炎性反应及其与预后的关系  

Change of inflammatory response before and after smoking cessation and its effect on prognosis in patients with acute coronary syndrome

作　　者：潘李莉[1] 夏艳[1] 方盈[1] 李芬[1] 杨慧敏[1] 王朝晖[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心血管内科,湖北武汉市430022

出　　处：《心血管康复医学杂志》2006年第2期188-189,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：探讨急性冠状动脉综合征(ACS)患者戒烟前、后炎性反应及其与预后的关系。方法：80例 ACS 患者, 在常规治疗和护理基础上,观察戒烟前、后血炎性因子的变化及其对预后的影响和随访期急性心脏事件的发生情况。结果：本组 ACS 者中,吸烟者炎性因子的水平显著高于非吸烟者(P＜0.001),吸烟者成功戒烟后炎性因子可降至正常水平,戒烟成功者预后显著优于戒烟未成功者(P＜0.01)。结论：①吸烟是 ACS 炎性反应的重要激活因素；②戒烟能显著改善 ACS 者的预后。Objective： To explore the change of inflammatory response before and after smoking cessation and its effect on prognosis in patients with acute coronary syndrome （ACS）. Methods ： The 105 ACS patients, including 80 smokers and 25 no-smokers were given routine treatments, The serum concentrations of inflammatory factors before and after smoking cessation were examined with enzyme-linked immunosorbent assay （ELISA） and incidence of acute cardiac event in follow-up was investigated in all subjects. Results ： Compared with no-smokers, smokers exhibited significant- ly higher levels of inflammatory factors （P〈0. 001 ）. Incidence of acute cardiac event in follow-up was markedly lower in patients with successfully smoking cessation than those of failing cigarette withdrawal （P〈0. 01）. Conclusion. Smoking is an important factor inducing the activation of inflammatory response in ACS. Smoking cessation can greatly improve the prognosis of ACS patients.

关 键 词：冠状动脉疾病 戒烟 预后 

分 类 号：R473.509[医药卫生—护理学]