原发性高血压患者血浆脑钠素含量及其临床意义  

A Clinical Study of the Serum Brain Natriuretic Peptide Level in Patients with Essential Hypertention

作　　者：王联发[1] 吴振西[1] 尹欣[1] 张树林[2] 李鲁光[2] 

机构地区：[1]解放军第105医院心内科,安徽合肥230031 [2]解放军北京军区总医院心内科

出　　处：《中国微循环》2006年第2期138-140,共3页Journal of Chinese Microcirculation

摘　　要：目的探讨原发性高血压(EH)患者血浆脑钠素含量及其临床意义。方法采用免疫放射分析法测定122例EH患者和36例对照组血浆BNP浓度;用心脏彩色多普勒超声诊断仪器测定左室质量指数(LVMI)。结果EH患者BNP浓度显著高于对照组(P<0.01),且EH伴LVH者BNP浓度明显高于EH无LVH者,差异有非常显著性(P<0.01);EH患者不同分级间、不同病程、不同年龄和不同性别间的血浆BNP浓度比较,差异无显著性(P>0.05)。结论EH患者血浆BNP水平明显升高,且与LVH密切相关;BNP浓度的测定可望成为EH患者LVH的一项诊断指标。Objective To investigate the clinical significance and the serum brain natriuretic peptide （BNP） level in patients with essential hypertention（EH）. Methods 122 patients with Eli and 36 control subjects were investigated by measuring the serum BNP level. Left ventrieular mass index（LVMI） was determined by two dimensional eehocardiography. Results The serum BNP level in patients with Eli were markedly higher than that in control subjects（P 〈0.01）, furthermore, the serum BNP level was significantly increased（P 〈0.01） in hypertensive patients with left ventrieular hypertrophy（LVH） as compared with those without LVH. However, the serum BNP level was not significantly increased（ P 〉 0.05） in hypertensive patients with different class, courses, ages and gender. Conclusion These rusults indicate that the extent of BNP level increase is closely correlative with the LVH, so the serum BNP level may be a diagnosis marker for the hypertensive patients with LVH.

关 键 词：原发性高血压 脑钠素 左室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]