冠心病患者血浆白细胞介素-18和γ-干扰素的变化  

Levels of plasma interleukin-18 and interferon-γ in patients with coronary heart disease

作　　者：王淑斐[1] 许金成[1] 梁庆祥[1] 

机构地区：[1]南方医科大学附属深圳宝安医院防保科,广东深圳518101

出　　处：《中国危重病急救医学》2006年第4期237-239,共3页Chinese Critical Care Medicine

基　　金：广东省医学科研基金资助项目(A2001488)

摘　　要：目的探讨白细胞介素18(IL18)和γ干扰素(IFNγ)在冠心病发病过程中的作用及其临床意义。方法采用酶联免疫吸附法(ELISA)检测45例冠心病患者和30名正常人血浆IL18和IFNγ水平,分析二者间的相关性以及与冠心病病情程度的关系。结果冠心病患者血浆IL18及IFNγ水平均较正常人增高〔IL18:(373.6±176.7)ng/L比(226.3±88.9)ng/L,P<0.01;IFNγ:(1.769±0.087)ng/L比(0.087±0.038)ng/L,P<0.01〕,且两者呈显著正相关(r=0.788,P<0.01),不同病情的冠心病患者之间血浆IL18和IFNγ水平差异显著,并随病情的加重而升高(P均<0.01),冠心病合并心力衰竭者血浆IL18和IFNγ水平亦较无心力衰竭者显著增高(P均<0.01)。结论血浆IL18和IFNγ可能共同参与冠心病的发生与发展过程。监测两者的血浆水平可能对判断冠心病病情有一定的参考价值。Objective To investigate the role of interleukin - 18 （IL - 18） and interferon -γ（IFN -γ） in coronary heart disease （CHD）. Methods The levels of plasma IL - 18 and IFN -γ in 45 patients with CHD and 30 normal volunteers were determined by enzyme linked immunoadsorbent assay （ELISA）. The correlation between the levels of these two cytokines and the relationship between their levels and the state of CHD were analyzed. Results The plasma levels of IL - 18 and IFN -γ in patients with CHD were increased significantly when compared to those in normal controls [IL - 18： （373. 6±176.7） ng/L vs. （226.3±88. 9） ng/L, P〈0. 01; IFN -γ： （1. 769±0. 087） ng/L vs. （0. 087±0. 038） ng/L, P〈0. 01]. The two cytokines were positively correlated significantly （r=0. 788, P〈0. 01）]. The plasma levels of IL - 18 and IFN -γ were significantly different in different states of CHD, and they increased with the aggravation of CHD respectively （all P〈0. 01）. Moreover, the plasma levels of IL - 18 and IFN -γ in patients complicated with heart failure （HF） were higher than those not complicated with HF, respectively （all P〈 0. 01）. Conclusion The findings suggest that IL - 18 and IFN -γ may participate in the pathogenesis and progression of CHD. The plasma levels of two cytokines may be used as parameters of estimation the morbid state of CHD.

关 键 词：冠心病 白细胞介素-18 Γ-干扰素 

分 类 号：R541.4[医药卫生—心血管疾病]