多基因离散性状QTL连锁分析方法  

Methodology of QTL's Linkage Analysis for Discrete Traits Controlled by Polygenes

作　　者：殷宗俊[1] 张勤[2] 

机构地区：[1]安徽农业大学动物科技学院,合肥230036 [2]中国农业大学动物科技学院,北京100094

出　　处：《遗传》2006年第5期578-582,共5页Hereditas（Beijing)

基　　金：国家重点基础研究发展规划(编号:G2000016103);安徽省教育厅项目(编号:2002jq126;2004kj151)资助~~~

摘　　要：动物中有许多重要的离散性状,与常规的数量性状类似,其遗传基础受多基因控制并受到环境因子的修饰。由于多基因离散性状的表型特殊性,利用常规的QTL连锁分析方法很难获得理想的统计效果,相应地发展了许多基于广义线性模型框架内的非线性方法。文章就目前离散性状的QTL连锁分析方法作简要综述,并对可预期的改进方法进行了展望。Many characters of biological interest and economical importance that are not inherited in a simple Mendelian fashion vary in a discrete form. These traits are called complex discrete traits. A complex discrete trait is presumably controlled by several genes, and characteristic of the trait is modified by environmental effects. Although methods of mapping QTL for continuous quantitative characters have been well developed, such methods for discrete characters are not available yet. So many non-linear methods were developed under the framework of the generalized linear model. In this paper, we reviewed the recent progress and improvement of the methods for QTL mapping in this field.

关 键 词：离散性状 QTL 连锁分析 广义线性方法 

分 类 号：Q343.241[生物学—遗传学]