培哚普利联合氟伐他汀对血清脂蛋白(a)的影响  

Effects of combined use of perindopril and fluvastatin sodium on lipoprotein(a)

作　　者：彭丽萍[1] 刘晶晶[1] 刘淑雨 李淑翠[3] 

机构地区：[1]中南大学湘雅三医院心内科,长沙市410013 [2]山东省委机关医院内科 [3]滨州医学院药理学教研室

出　　处：《滨州医学院学报》2006年第2期86-87,共2页Journal of Binzhou Medical University

摘　　要：目的观察培哚普利联合氟伐他汀对血清脂蛋白(a)[Lp(a)]浓度的影响。方法采用酶联免疫双抗体夹心法(ELISA)分别检测52例单独服用氟伐他汀(40 mg/d)及67例联合服用培哚普利(4 mg/d)和氟伐他汀(40 mg/d)患者前后血清(Lp(a)浓度的变化。结果单独服用氟伐他汀患者的Lp(a)浓度较前下降,而联合服用培哚普利及氟伐他汀患者的Lp(a)浓度较前下降更明显。结论联合服用培哚普利和氟伐他汀能更明显降低血清Lp(a)的浓度。Objective To study the effects of combined use of perindopfil and fluvastatin sodium on serum concentration of lipoprotein（a）. Methods Lp（a） in serum was determined by ELISA in 52 patients who took fluvastatin sodium only and 67 patients who took both fluvastatin sodium and perindopril. Results There was a little decrease of the concentration of Lp （a） in the patients who took fluvastatin sodium only. And there was a significient decrease of the concentration of Lp（ a） in the patients who took both fluvastatin sodium and perindopril. Conclusion Combined therapy of fluvastatin sodium and perindopril could efficiently decrease serum concentration of Lp（ a）.

关 键 词：培哚普利 氟伐他汀 血清脂蛋白(a) 

分 类 号：R972.6[医药卫生—药品]