Graves病甲亢和CD40基因单核苷酸多态性的相关性  

The Association between Graves' Disease and a C/T Single-Nucleotide Polymorphism in the CD40 Gene

作　　者：罗惠辛[1] 张鹏[1] 邱明才[1] 

机构地区：[1]天津医科大学总医院内分泌科,300052

出　　处：《天津医药》2006年第4期229-230,共2页Tianjin Medical Journal

摘　　要：目的:探讨CD40基因5′非翻译区域C/T多态性和Graves病(GD)甲亢发病的相关性。方法:采用序列特异性聚合酶链式反应-限制性内切酶酶切长度多态性(PCR-RFLP)方法分析106例GD甲亢患者和106例正常对照者CD40基因5′非翻译区域C/T多态性。结果:GD甲亢患者CC基因型明显高于正常对照组(49.1%vs32.1%),C等位基因频率明显高于正常对照组(63.7%vs50.5%)。结论:CD40基因5′非翻译区域的C等位基因和GD甲亢相关。Objective： To investigate the C/T polymorphism in the 5′-untranslated region（UTR） of the CD40 gene and its relationship with Graves＇disease. Methods： The C/T polymorphism in the CD40 gene 5′ UTR in one hundred and six GD patients and one hundred and six normal patients （normal） was analyzed by using polymerase chain reaction-restrictionfragment length polymorphism （PCR-RFLP）. Results： The CC genotype of GD patients was significantly higher than that in the normal subjects （49.1% vs 32.1%）,on the other hand, the frequency of the C allele was significantly higher than that in the normal subjects （63.7% vs 50.5%）. Conclusion： The C allele in the 5′-untranslated region of the CD40 gene may be associated with etiological factor of GD.

关 键 词：格雷夫斯病 甲状腺功能亢进症抗原 CD40多态性 单核苷酸 

分 类 号：R581.11[医药卫生—内分泌] R394[医药卫生—内科学]