宣发膜原方对胶原免疫性关节炎大鼠关节滑膜细胞超微结构的影响  

Effects of Xuanfa Moyuan Prescription on Ultrastructure of Articular Synovial Cells in Collagen Immune Arthritis Rats

作　　者：贾红伟[1] 赵宁[1] 李艳[1] 张皖东[1] 吕诚[1] 赵宏艳[1] 铃木聪[2] 王少君[1] 滕静如[1] 吕爱平[1] 

机构地区：[1]中国中医科学院基础理论研究所,北京市东直门内南小街16号100700 [2]北京中医药大学

出　　处：《中医杂志》2006年第4期301-302,共2页Journal of Traditional Chinese Medicine

基　　金：国家自然研究基金资助项目(39870952)

摘　　要：目的:探讨宣发膜原方对胶原免疫性关节炎(CIA)的治疗机理,为研究类风湿性关节炎(RA)的发病和损伤机理提供实验依据。方法:以CIA作为RA的动物模型,以达原饮加减方作为宣发膜原法代表方,检测CIA大鼠踝关节病理改变及膝关节滑膜组织超微结构的变化。结果:宣发膜原方可以有效地减轻CIA大鼠病理损伤,提高滑膜细胞中B型滑膜细胞的比例,减少滑膜细胞中的高尔基体、粗面内质网等细胞器。结论:宣发膜原方能够减轻CIA病理损伤,改善滑膜细胞超微结构。Objective： To explore mechanisms of Xuanfa Moyuan Prescription in treatment of collagen immune arthritis（CIA）,so as to provide experimental basis of pathogenesis and injury mechanism of rheumatoid arthritis （RA）. Methods： Using CIA as RA animal model and modified Dayuan Yin as a representative prescription of the Xuanfa Moyuan Method, pathological changes of the ankle joint and the ultrastructure of synovial tissue of the knee joint in CIA rats were investigated. Results：Xuanfa Moyuan Prescription could effectively alleviate pathological injury, increase the ratio of B type synovial cell in the synovial cells in CIA rats, and reduce Golgi body, rough surface endoplasmic reticulum and other cell organs in the synovial cells. Conclusion： Xuanfa Moyuan Prescription can alleviate pathological injury of CIA and improve ultrastructure of the synovial cell.

关 键 词：关节炎 免疫学滑膜 超微结构 宣发膜原方 

分 类 号：R285[医药卫生—中药学]