Synthesis of α-Arylated Esters from Aryl Halides  

作　　者：Wei DENG Ye Feng WANG Lei LIU Qing Xiang GUO 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei 230026

出　　处：《Chinese Chemical Letters》2006年第5期595-598,共4页中国化学快报（英文版）

摘　　要：An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α- arylalkanoic acids.An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α- arylalkanoic acids.

关 键 词：Cross coupling reaction CUI ethyl acetoacetate aryl halide α-arylalkanoic acids. 

分 类 号：O625.523[理学—有机化学]