抑肽酶血液麻醉在成人法乐四联症矫治术中的应用  

Blood anaesthesia with aprotinin in adult tetralogy of fallot surgery in adult

作　　者：韦华[1] 邓劲松[1] 张日英[1] 李波[1] 

机构地区：[1]高州市人民医院麻醉科

出　　处：《中国心血管病研究》2006年第5期361-363,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨抑肽酶在成人法乐四联症矫治术中的血液保护作用。方法30例法乐四联症(TOF)手术患者,随机分为两组:观察组于体外循环前、中应用中等剂量抑肽酶;对照组不用抑肽酶。结果观察组术后出血量、输血量、二次开胸例数、血FDP含量均明显少于对照组(P<0.01),CPB后PLT计数多于对照组(P<0.05)。结论中等剂量抑肽酶,作为一项血液保护措施能有效减少成人紫绀型心脏病手术后出血量及手术用血量。Objective To explore the protective effects of blood anaesthesia with aprotinin in tetralogy of Fallot （TOF） surgery in adult. Methods 30 cases of TOF surgery were randomized into two groups： one group（n= 15） received aprotinin 4× 10^6 KIU before and during cardicopulmonefry bypass （CPB）, and the other group （n=15） did not. Results Bleeding volume, volume of blood transfuse, and the frequency of secondary-open-thorax, the fibrin degradation products （FDP）of blood in the aprotinin group is obviously less than the control groups （P〈0.01）.While the plate counter after CPB is higher than the control group （P〈0.05）. Conclusion Using moderate dose of aprotinin can effectively reduce the bleeding volume and transfused volume of blood in TOF operation in adult.

关 键 词：抑肽酶 法乐四联症 失血 手术 

分 类 号：R654.2[医药卫生—外科学]