高血压与临床很可能帕金森病的关联性:林县营养干预4335人队列人群资料分析(英文)  

Correlation between hypertension and clinical probable Parkinson disease:Cohort analysis of 4 335 people in Linxian County with nutritional intervention

作　　者：范金虎[1] 张亚黎[1] 刘颖[2] 孙秀娣[1] 乔友林[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所,北京市100021 [2]大连医科大学附属第二医院神经内科,辽宁省大连市113000

出　　处：《中国临床康复》2006年第20期157-159,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:中国林县是世界食管癌、贲门癌最高发地区之一,该地区居民普遍存在营养素缺乏。近年来,国际上围绕帕金森病的病因进行许多研究,认为遗传因素、年龄、环境因素、饮食营养因素、吸烟等是帕金森病的危险因素。越来越多的研究认为原发性高血压可能与血管性帕金森综合征发病有关,长期高血压更易导致血管性帕金森综合征。目的:探讨林县营养缺乏人群高血压与临床很可能帕金森病之间的关系,为早期防治帕金森病提供理论依据。设计:横断面调查。对象:来源于参加林县营养干预试验且1985年试验开始进入队列时的55岁及以上人群,共计4335人。方法:采用前瞻性队列研究方法。①病例的筛查:采用美国哥白县帕金森病问卷调查与简单的神经系统体格检查相结合的办法。②帕金森病的诊断:以英国帕金森病协会脑库临床诊断标准作为此次筛查帕金森病的临床诊断标准。在调查中对具有帕金森症状的对象,还进一步作临床很可能帕金森病、临床可能帕金森病的诊断。其中临床很可能帕金森病的诊断标准:必须具备下列症状之中的两项(静止性震颤,肌张力增高,运动迟缓,姿势反射受损)或出现下列症状之一(静止性震颤,肌张力增高,运动迟缓)且是单侧起病,即可诊断为临床很可能帕金森病。临床可能帕金森病的诊断标准:出现下列症状之一(静止性震颤,肌张力增高,运动迟缓,姿势反射受损)即可诊断为临床可能帕金森病。③高血压的判定:收缩压≥140mmHg或舒张压≥90mmHg为高血压。资料处理采用线性趋势检验及非条件Logistic回归。主要观察指标:病例确诊情况、高血压与临床很可能帕金森病的关系。结果:参加1985/1991林县营养干预试验的林县居民中55岁及以上老年人4335人参加了1999/2000帕金森病筛查,男2008人穴46.32%雪,女2327人穴53.68%雪。1985年研究对象经问�BACKGROUND： Linxian County of China is one of the areas with the highest incidence of esophageal cancer and gastric cardia cancer in the world, and nutrition-deficiency is widely existing in local people. In recent years, many researches around the world revealed that the cause of Parkinson disease （PD） is related to factors of gene, age, environment, diet, nutrition and smoking. More and more studies confirmed that primary hypertension may be in relation to vascular Parkinsonism （VP） and long-term hypertension was apt to VP. OBJECTIVE： To investigate the relationship between hypertension and clinical probable Parkinson disease （PPD） in nutrition-deficient population of Linxian County and provide a theoretical basis for early prevention and treatment of PD. DESIGN： Cross-sectional study. PARTICIPANTS： A total of 4 335 subjects aged over 55 years were selected. These subjects have taken part in the nutritional intervention study of Linxian County and first entered in the cohort study in 1985. They were enrolled in the nutritional intervention study in Linxian County in 1985. METHODS： A prospective cohort study was conducted. ①Case screening： PD questionnaire （used in American Gebai County） combined with general neurological examination were adopted. ②The diagnosis of PD： Clinical diagnostic criteria of UK Parkinson Disease Society Brain Bank were taken as the criteria for screening PD. Further evaluations were undertaken for clinical PPD and clinical possible PD on subjects who had PD symptoms. The diagnostic criteria of clinical PPD： Subjects were diagnosed as having clinical PPD if they presented any two of the following two cardinal features （resting tremor, hypermyotonia, bradykinesia and impairment of postural reflexes） or presented any one of the following features （resting tremor, hypermyotonia and bradykinesia）. Diagnostic criteria of clinical possible PD： Subjects were diagnosed as having clinical possible PD when presented any one of the following fou

关 键 词：高血压 帕金森病 流行病学研究 

分 类 号：R544.1[医药卫生—心血管疾病]