蒙古族人群胰岛素抵抗与原发性高血压的关系(英文)  

Association between insulin resistance and primary hypertension in Chinese Mongolian population

作　　者：叶宏[1] 刘丽娟[1] 张永红[2] 王艳华[1] 佟伟军[2] 李永山 黄桂蓉[1] 冯华 王剑 巴图 

机构地区：[1]哈尔滨医科大学公共卫生学院流行病教研室,黑龙江省哈尔滨市150081 [2]苏州大学放射医学与公共卫生学院流行病教研室,江苏省苏州市215123 [3]科左后旗防疫站,内蒙古自治区通辽市02800 [4]通辽市疾病控制中心,内蒙古自治区通辽市02800

出　　处：《中国临床康复》2006年第20期162-164,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金主任基金资助项目(30040040)~~

摘　　要：背景:胰岛素抵抗可能是高血压的危险因素,但不同种族人群中胰岛素抵抗与高血压的关系不一致。目的:分析蒙古族人群胰岛素抵抗与高血压的关系。设计:现况调查。单位:哈尔滨医科大学公共卫生学院流行病教研室。对象:2001年6月在现况调查基础上,选择内蒙古通辽市科左后旗部分原发性高血压患者和血压正常者,均为蒙古族,进一步核实并测量血压,签署知情同意书后纳入本调查,排除其他心血管疾病患者。入选对象共232人,年龄30～60岁。方法:采取整群抽样的方法,选取原发性高血压患者115人、血压正常者117人作为调查对象。采用标准化方法测量身高、体质量、腰围和臀围,腰臀比即腰围/臀围。体质量指数<24kg/m2或腰臀比<0.9,即体质量或体型偏于正常。应用血糖仪测定血糖,应用放射免疫法测定胰岛素和C-肽,胰岛素抵抗程度以胰岛素敏感指数来评价,胰岛素敏感指数=-ln眼血糖穴mmol/L雪×胰岛素穴mU/L雪演。考虑到体质量指数和腰臀比对胰岛素敏感指数的影响,将体质量指数穴≥24kg/m2和<24kg/m2雪、腰臀比穴≥0.9和<0.9雪分层后,进行统计学分析。主要观察指标:两组调查对象的胰岛素敏感指数。结果:纳入调查对象232人,全部进入结果分析,无脱落。①两组调查对象胰岛素敏感指数比较:高血压组的胰岛素敏感指数略低于血压正常组,但差异无显著性意义眼-3.56±0.27,-3.50±0.20(P>0.05)演。②按体质量指数和腰臀比分层后两组调查对象胰岛素敏感指数比较:当体质量指数<24时,高血压组胰岛素敏感指数显著低于血压正常组眼-3.56±0.27,-3.48±0.17(F=5.037熏P<0.05)演;当腰臀比<0.9时,高血压组的胰岛素敏感指数显著低于血压正常组眼-3.57±0.27,-3.49±0.20(F=4.537熏P<0.05)演。结论:在蒙古族非肥胖人群中,胰岛素抵抗与原发性高血压的发生可能有关。BACKGROUND： Insulin resistance may be a risk factor for hypertension, but the relationship between insulin resistance and hypertension are quite different from different race or nationalities. OBJECTIVE： To analyze the relationship between insulin resistance and hypertension in Chinese Mongolian population. DESIGN： Prevalent investigation. SETTING： Staff Room of Epidemiology, Public Health College of Harbin Medical University. PARTICIPANTS： Totally 232 patients with primary hypertension and persons with normal blood pressure, aged from 30-60 years from Kezuohouqi of Tongliao city in June 2001 based on the prevalent survey, and they all Mongoloid population. Examination was performed and blood pressure was measured. They were involved in this investigation after signing the consent. Other cardiovascular disease patients were excluded. METHODS： A total of 115 patients with primary hypertension and 117 normotensives were selected with cluster sampling method. Height, body mass, waistline, hip line and waist-to hip ratio （WHR）, i.e. waist line/ hip line were standardization method. Body mass index （BMI） 〈 24 kg/m^2 or waist-to-hip ratio （WHR） 〈 0.9, body mass or somatotype was partial to normal. Blood glucose was detected with glucose meter. Radio-immunoassay （RIA） were utilized to measure insulin and C-peptide. Degree of insulin resistance was determined by means of insulin sensitivity index （ISI）, ISI =-In [glucose （mmol/L） x insulin （mU/L）]. After considering the effect of BMI and WHR as well as the stratification of BMI （≥24 kg/m^2 and 〈 24 kg/m^2） and WHR （≥ 0.9 and 〈 0.9）, statistical analysis was performed. MAIN OUTCOME MEASURES： ISI Of the investigational subjects of the two groups. RESULTS： Totally 232 included investigational subjects were involved in the result analysis, without drop out. ①Comparison of ISI of the investigational subjects of the two groups： The ISI of the hypertension group was slightly lower than that of the

关 键 词：蒙族 胰岛素抗药性 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]