脉冲电磁场对高胆固醇饮食兔左室功能的影响  

Effects of pulsed electromagnetic fields on left ventricular function in rabbits fed on a high-cholesterol diet

作　　者：张钰[1] 罗二平[1] 申广浩[1] 谢康宁[1] 吴小明[1] 

机构地区：[1]第四军医大学生物医学工程系军队卫生装备与计量学教研室,陕西西安710033

出　　处：《第四军医大学学报》2006年第8期757-759,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金资助项目(50077023)

摘　　要：目的:探讨低强度脉冲电磁场对长期进食高胆固醇饲料兔心功能的影响.方法:将30只雌性5mo龄新西兰大耳白兔随机分为3组(n=10):对照组、高脂组、磁场组.对照组用常规饲料喂养,高脂组和磁场组用高胆固醇饲料饲养.磁场组暴露于强度为4Gs的脉冲电磁场环境中(f=15Hz),暴磁时间为10h/d;饲养8wk后测定左室功能指标.结果:与对照组比较,高脂组左室射血时间显著缩短,射血前期和等容收缩期明显延长,PEP/LVET和ICT/LVET均显著增加(P<0.01),而磁场组的差异没有统计学意义(P>0.01);与高脂组比较,磁场组左心室射血时间延长(P<0.01)、射血前期及等容收缩期缩短(P<0.01)、PEP/LVET及ICT/LVET比值显著降低(P<0.01).结论:低强度脉冲电磁场能够显著改善左室功能.AIM： To investigate the effects of low-intensity pulsed electromagnetic fields （PEMFs） on left ventricular function in rabbits fed on a high-cholesterol diet. METHODS： Thirty female New Zealand rabbits were randomly divided into 3 groups （n=10 per group） ： control, hyperlipid and magnetic groups. The control group was fed on a normal diet and other groups were fed on a high-cholesterol diet. The magnetic group was exposed to 15 Hz PEMFs （4×10^-4 T and 10 h/d）. After 8 weeks, the parameters of left ventricular function were detected, and the changes were compared with each other. RESULTS： Compared with the control group, the parameters of hyperlipid group showed statistically significant differences （P 〈 0.01 ）, but the values of left ventricular ejection time （LVET）, preejection period （PEP）, isovolumic contraction time, （ICT）, PEP/LVET and ICT/LVET in the magnetic group didn＇t show any differences （P 〉0.01 ）. Compared with the hyperlipid group, the parameters of magnetic group showed statistically significant differences： LVET was prolonged, PEP and ICT were shortened, PEP/LVET and ICT/LVET were decreased （P 〈0.01 ）. CONCLUSION： Lowintensity PEMFs are effective in improving the cardiac function.

关 键 词：脉冲电磁场 左室功能 兔 

分 类 号：R312[医药卫生—基础医学]