环糊精和α-萘乙酸包络物的核磁共振研究  

NMR Study on Inclusion-complex of Cyclodextrin with α-Naphthylacetic Acid

作　　者：彭敏[1] 孔旭新[1] 余亦华[1] 陈群[1] 

机构地区：[1]华东师范大学物理系教育部光谱学与波谱学重点实验室,上海200062

出　　处：《高等学校化学学报》2006年第5期939-943,共5页Chemical Journal of Chinese Universities

基　　金：国家'八六三'计划项目(批准号:2004AA302080);上海市科委纳米专项基金(批准号:0452nm028)资助

摘　　要：利用溶液2D-ROESY谱、13C固体高分辨谱以及自扩散系数测量等核磁共振技术,研究了环糊精(CD)和α-萘乙酸(α-NAA)的相互作用.结果表明,α-CD和β-CD均能与α-NAA形成包络物,但是由于尺寸更为匹配,-βCD与α-NAA体系的包络相互作用强度明显比α-CD和α-NAA体系的大;通过测量-βCD与α-NAA混合溶液中α-NAA的自扩散系数,计算出包络物结合与解离的平衡常数,以此为基础对-βCD/α-NAA体系在实现α-NAA缓释方面的应用方式进行了探讨.The interactions of α-naphthylacetic acid （α-NAA） with α-cyclodextrin （α-CD） and β-cyclodextrin （β-CD） were studied by NMR diffusion measurements, ^1H-^1H ROESY and solid-state high-resolution ^13C NMR spectroscopy. Both α-CD and β-CD are found to be able to form inclusion-complex with α-NAA. The complex formed by β-CD and α-NAA are more stable than that formed by α-CD and α-NAA, due to the effect of cavity size. The association constant of β-CD/α-NAA complex was calculated from the self-diffusion coefficients of α-NAA. The application of β-CD/α- NAA system in drug release was discussed.

关 键 词：NMR ROESY ^13C CP/MAS 自扩散系数 包络物 

分 类 号：O631.1[理学—高分子化学]