多吡啶钴(Ⅲ)配合物与Zn^(2+)形成的新型“关-开”荧光探针  

A Newly Designed off-on Luminescent Probe Formed by Polypyridyl Cobalt(Ⅲ) Complex and Zn^(2+)

作　　者：张黔玲[1] 刘剑洪[1] 任祥忠[1] 李翠华[1] 张培新[1] 刘建忠[2] 计亮年[2] 

机构地区：[1]深圳大学师范学院化生系,深圳518060 [2]中山大学教育部基因工程重点实验室,广州510275

出　　处：《无机化学学报》2006年第5期885-889,共5页Chinese Journal of Inorganic Chemistry

基　　金：广东省自然科学基金博士启动基金(No.04300882);深圳市科技计划资助项目(No.200328)

摘　　要：The formation of heterobimetallic complex [Co(bpy)2(ODHIP)Zn]5+ by [Co(bpy)2ODHIP]3+ and Zn2+ was investigated. The luminescent property of complex was also studied. The results indicated that the nonluminescent monometallic complex [Co(bpy)2ODHIP]3+ could coordinated with Zn2+ to form the luminescent heterobimetallic complex [Co(bpy)2(ODHIP)Zn]5+, the emission intensity increased as increasing the amounts of Zn2+. The luminescence became the strongest at the ratio of CZn / CCo of 1. After binding to DNA, [Co(bpy)2ODHIP]3+ must change its binding mode from partial intercalation to intercalation to make the peripheral coordination site on the ODHIP ligand accessible for Zn2+, the coordination occurred from the opposite side of helix with respect to the intercalated [Co(bpy)2ODHIP]3+, and the luminescent heterobimetallic complex [Co(bpy)2(ODHIP)Zn]5+ was formed. On the other hand, [Co(bpy)2(ODHIP)Zn]5+ bound to DNA by intercalation and situated the region of the intercalated [Co(bpy)2ODHIP]3+ between the base pairs of DNA, while the remained monometallic complex [Co(bpy)2ODHIP]3+ bound to DNA by partial intercalation.The formation of heterobimetallic complex [Co（bpy）2（ODHIP）Zn]^5＋by [Co（bpy）2ODHIP]^3＋ and Zn^2＋ was investigated. The luminescent property of complex was also studied. The results indicated that the nonluminescent monometallic complex [Co（bpy）2ODHIP]^3＋ could coordinated with Zn^2＋ to form the luminescent heterobimetallic complex [Co（bpy）2（ODHIP）Zn]^5＋, the emission intensity increased as increasing the amounts of Zn^2＋. The luminescence became the strongest at the ratio of Czn/Cco of 1. After binding to DNA, [Co（bpy）2ODHIP]^3＋ must change its binding mode from partial intercalation to intercalation to make the peripheral coordination site on the ODHIP ligand accessible for Zn^2＋, the coordination occurred from the opposite side of helix with respect to the intercalated [Co（bpy）2ODHIP]^3＋, and the luminescent heterobimetallic complex [Co（bpy）2（ODHIP）Zn]^5＋ was formed. On the other hand, [Co（bpy）2（ODHIP）Zn]^5＋ bound to DNA by intercalation and situated the region of the intercalated [Co（bpy）2ODHIP]^3＋ between the base pairs of DNA, while the remained monometallic complex [Co（bpy）2ODHIP]^3＋ bound to DNA by partial intercalation.

关 键 词：多吡啶钴配合物 DNA ZN^2+ 荧光 

分 类 号：O614.241[理学—无机化学] O614.812[理学—化学]