青蒿素在亚铁离子催化下的裂解产物-3-羟基脱氧青蒿素  

The reaction product of QHS with ferrous ion-3-hydroxy deoxyartemisinin

作　　者：李淑辉[1] 乐征宇[1] 高坡[1] 

机构地区：[1]黑龙江大学化学化工与材料学院,黑龙江哈尔滨150080

出　　处：《黑龙江大学自然科学学报》2006年第2期253-256,共4页Journal of Natural Science of Heilongjiang University

基　　金：黑龙江省自然科学基金资助项目(B0109);黑龙江大学杰出青年基金资助项目(J200206)

摘　　要：用硫酸亚铁引发青蒿素的自由基裂解反应,对主产物之一的3-羟基脱氧青蒿素进行了单晶培养和X射线的表征,运用环Puckering分析方法对结构中环的构象进行了半定量描述。其中六元环分别呈现微扭曲的椅式构象、严重扭曲的椅式构象及半椅式构象;五员环的构象呈信封式,为探索构效关系、开发新型抗疟药物提供了必要的理论依据。Artemisinin was reacted with ferrous sulphate to give free radical products. One of the two major products was characterized by single crystal X - ray diffraction. Here the rings configuration in the crystal structure is described clearly by semi - quantitative ring puckering analysis. The six - membered rings exhibit slightly distorted chair, extremely distorted chair and half- chair conformation respectively, and the five - membered ring exhibits an envelope conformation. The result may provide a support for research of structure - function relation and exploitation of new antimalarial drugs.

关 键 词：青蒿素 3-羟基脱氧青蒿素 晶体结构 Puckering分析 

分 类 号：O614[理学—无机化学]