听觉诱发电位指数、双频指数与咪达唑仑镇静作用的相关性研究  

Correlation Analysis of Auditory Evoked Potentials Index and Bispectral Index with Midazolam-induced Sedation

作　　者：葛圣金[1] 薛张纲[1] 庄心良[2] 周晓敏[1] 

机构地区：[1]复旦大学附属中山医院麻醉科,上海200032 [2]上海市第一人民医院麻醉科,上海200080

出　　处：《中国临床医学》2006年第2期317-319,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:分析听觉诱发电位指数(A-line ARX-index,AAI)、双频指数(bispectral index,BIS)与咪达唑仑镇静作用的相关性。方法:选择14例美国麻醉医师协会体格分级Ⅰ～Ⅱ级、在下胸腰段硬膜外阻滞下行妇科手术的成年病人。监测AAI 和BIS,依据观察者警觉与镇静评分(observers assessment of the alertness／sedation seale,OAA／S评分)评估镇静程度。术中每隔5min静注咪达唑仑0．5 mg,直至OAA／S评分达到1分。分析AAI、BIS与OAA／S评分值之间的相关性。结果: 诱导期,AAI、BIS随病人镇静程度加深明显降低,且与OAA／S评分值显著相关(Speannan等级相关系数r=0．973和0． 945,均P<0．001)。恢复期病人表现为骤醒,AAI、BIS亦快速上升。结论:AAI、BIS均可定量、准确地反映咪达唑仑的镇静效果。Objective： To study the correlationship of the autoregressive model with exogenous input extracted auditory evoked potentials index （A-line ARX index, AAD, bispectral index （BIS） with midazolam-induced sedation. Methods.. Fourteen ASA Ⅰ～Ⅱ adult patients, undergone elective gynecological surgery under low-thoracolumbar epidural anesthesia were studied. An intravenous bolus dose of midazolam （0. 5mg） was administered every 5 minutes until the score level 1 of the observer＇s assessment of the alertness/ sedation scale （OAA/S） reached. AAI, BIS were monitored on different OAA/S score levels and their correlation with midazolam-induced sedation was analyzed. Results： During the onset phase, Both AAI and BIS were distinctly reduced as patients＇ OAA/S scores decreased, and correlated with sedation significantly （the coefficient of Spearman＇s rank correlation r=0.973,0.945,P 〈 0. 001）. AAI correlated better than BIS （P 〈 0. 05） with the scores. During the recovery phase, all patients got awake （OAA/S scores 4 5） abruptly, and AAI, BIS increased speedily. Conclusion：Both AAI and BIS can assess midazolam-induced sedation quantitatively and accurately.

关 键 词：听觉诱发电位指数 双频指数 咪迭唑仑 清醒镇静 

分 类 号：R971.1[医药卫生—药品]