气管插管中小剂量琥珀胆碱的应用  

Efficacy of Low-dose Succinylcholine in Oral Intubation

作　　者：吕克重[1] 穆殿超[1] 李铁成[1] 汪向东[1] 

机构地区：[1]辽宁锦州医学院附属第三医院麻醉科,辽宁锦州121000

出　　处：《中国临床医学》2006年第2期328-329,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:研究在全麻诱导气管插管中小剂量琥珀胆碱的作用与不良反应。方法:选择50例临床ASAⅠ～Ⅱ级择期全麻手术病人,在全麻诱导中应用不同剂量(1．5 mg／kg和0．5 mg／kg)的琥珀胆碱,观察心血管系统、肌松作用。不良反应和并发症的变化。结果:小剂量起效晚约2．24min,呼吸暂停时间短约2．17min,肌松作用和插管条件满意,对心血管系统的影响与大剂量相比无显著差异,肌颤及术后肌痛的发生亦无显著差异(P>0．05)。结论:与大剂量比较,小剂量也能提供满意的插管条件,不良反应及并发症并无相应减轻。Objective： To study the efficacy and safery of low-dose succinylcholine in the Intubation of general anaesthesia. Methods：50 patients（ASA grade Ⅰ-Ⅱ） underwent general aneasthesia were allocated to receive different dose（0. 5mg/kg and 1. 5mg/kg） succinylcboline, The alteration of cardiovascular system, muscular relaxation, adverse reaction and complication were observed. Results：Pre-effect time of low-dose is about 2. 24 min, longer than that of the large-dose. Duration of apnea was about 2. 17 min,shorten than that of large-dose. Situation of muscular relaxation and intubation condition was good. Effect of cardiovascular system did not differ significantly from that of large-dose（P〉0. 05）. Conclusion： Low-dose succinylcholine can provide satisfactory condition for intubation, although the adverse reaction and complication were not diminished correspondingly.

关 键 词：琥珀胆碱 小剂量 气管插管 

分 类 号：R971.8[医药卫生—药品]