7'-O-菊酰基井冈羟胺A的合成  

Synthesis of 7'-O-chrysanthemyl validoxylamine A

作　　者：郑鹛[1] 杜晓华[1] 浦晓莺[2] 沈宙[2] 徐振元[1] 

机构地区：[1]浙江工业大学催化加氢研究中心,绿色化学合成技术国家重点实验室培育基地,浙江杭州310014 [2]上海农药研究所,上海200032

出　　处：《农药》2006年第5期327-328,共2页Agrochemicals

摘　　要：将拟除虫菊酸酰化后,与井冈霉素A的水解产物井冈羟胺A反应,合成了3个未见报道的7'-O-菊酰基井冈羟胺A(4a￣4c),其结构经1HNMR、IR和MS确认。初步的生物活性测试显示,其中4a和4b均表现出一定的杀蚜虫活性,4b对纹枯病菌也表现出一定的抑制作用。Three previously unreported 7＇-O-chrysanthemyl validoxylamine A compounds （4a-4c） were synthesized after pyrethrum acylation followed by reacting with validoxylamine A, the hydrolysis product of validamycin A. Their structures were confirmed by MS, ^1H-NMR, and IR spectra. Preliminary biological activity testing showed that 4a and 4b possessed activity against Aphis medicaginis and 4b also was active against Rhizoctonia solani.

关 键 词：7'-O-菊酰基片冈羟胺A 合成 生物活性 

分 类 号：TQ450.7[化学工程—农药化工]