苦参碱和阿苯达唑治疗小鼠继发性泡球蚴病的疗效观察  

Effect of matrine and albendazole on Echinococcus multilocularis infection in mice

作　　者：张睿[1] 景涛 傅宣英[1] 卫峥[1] 王琪 

机构地区：[1]兰州大学基础医学院病原生物学教研室,兰州730000 [2]甘肃省中药新药临床前研究重点实验室,兰州730000 [3]不详

出　　处：《中国人兽共患病学报》2006年第4期342-346,共5页Chinese Journal of Zoonoses

基　　金：甘肃省中药新药临床前研究重点实验室开放基金资助(No.GSKFKT-0408)

摘　　要：目的探讨中药苦参碱与阿苯达唑联用对小鼠继发性泡球蚴病的治疗效果。方法将感染泡球蚴小鼠随机分为四组,即:苦参碱组、阿苯达唑组、联合用药组和阴性对照组,另设空白组。小鼠泡球蚴病用药物治疗60天后,检测各小鼠泡球蚴湿重、胸腺指数、脾脏指数和抑囊率,并进行病理组织学和超微结构观察。结果苦参碱单独及与阿苯达唑联合用药均对小鼠泡球蚴有明显抑制作用(抑囊率分别为77.61%和89.88%),各治疗组泡球蚴的平均湿重与对照组比较有显著性差异(P<0.01);接种泡球蚴的各组与空白组比较,胸腺普遍缩小而肝、脾增大(P<0.05)。结论苦参碱对小鼠泡球蚴的生长有明显的抑制作用,尤其联合阿苯达唑治疗效果更好,说明两种药物具有协同治疗作用。To evaluate the effect of matrine（Mat） on experimental secondary Echinococcus multilocularis in mice and synergistic effect of combined administration with albendazole（ABZ ）, Mice infected with E. multilocularis were divided into four groups randomly,including Matrine alone.Albendanzole alone,combination of the two drugs as above and control. At the same time ,selecting healthy mice as blank. After being treated 60 days ,the mice were dissected. The major judging criteria including cyst wet weight,thymus index,spleen index , inhibition rate. and histopathological changes of cyst both microscopically and electron microscopically. Matrine alone or combination with Albendazole had obviously effect against growing of E. multilocularis cyst（Inhibition rates were 77.61% and 89.88N respectively）. There was significant difference in the cyst wet weight between therapeutical groups and control as shown by the results in mice（P 〈;0.01）; the thymus index in the blank group was lower than that in the Echinococcus multilocularis infection groups, but the spleen index in the blank group was higher than that in the Echinococcus multilocularis infection groups（P〈0.05）. Matrine had obvious inhibitory effec against E. multilocularis, The combination of the Matrine with Albendazole had stronger inhibition action, which indicated that Matrine could strengthen Albendazole＇s effect and had synergetic action with Albendazole against E.multilocularis.

关 键 词：泡球蚴病 苦参碱 阿苯达唑 

分 类 号：R532.32[医药卫生—内科学]