HpSA试验监测幽门螺杆菌感染根除效果的价值  

Evaluation of the Helicobacter pylori stool antigen test for monitoring eradication therapy

作　　者：李松森[1] 陈丰霖[2] 石峰[1] 潘玉红[1] 

机构地区：[1]福建医科大学附属协和医院检验科,福州350001 [2]福建医科大学附属协和医院消化科

出　　处：《中国人兽共患病学报》2006年第4期382-384,共3页Chinese Journal of Zoonoses

摘　　要：目的检测粪便幽门螺杆菌抗原(HpSA)水平在根除治疗期间及以后的变化,并评估根除治疗疗效检测的最佳时间。方法受试者为57例Hp阳性的病人,均接受了一周的三联疗法。根除治疗的结果由尿素呼气试验、细菌培养以及治疗结束后6周时的组织检查来判定。HpSA的水平则从治疗前到治疗后的12周,先后共检测9次。结果根除治疗获得成功组病人的HpSA在治疗结束后立即转阴并保持阴性。而治疗失败组的病人HpSA也在治疗结束后立即转阴,但在治疗结束后2周时又转为阳性。治疗失败组在根除治疗开始后第4天HpSA试验的平均吸收值显著高于根治成功组。HpSA试验诊断(根除成功与否)的准确率在治疗2周以后增长到>90%。治疗结束后第2、6、8、12周HpSA的诊断准确率与治疗结束后第4周相比无显著差异。结论根除成功组病人的HpSA水平在治疗后的变化情况同失败组显著不同。HpSA的检测对于评估根治疗效是非常有意义的,且评估治疗效果的适当时机是在根除治疗后2周以后。To clarify the levels of time course of the Helicobacter pylori stool antigen （HpSA） test during and after eradication therapy and to determine the appropriate time of measurement of HpSA to evaluate eradication, 57 patients positive for H. pylori, were underwent a one week regimen of triple therapy, and the outcome of the eradication therapy was judged by urea breath test, culture, and histology 6 wk after the end of treatment. The HpSA level was serially measured nine times from before therapy until 12 wk after the end of therapy. In the group with successful eradication, HpSA became negative imh mediately after the end of therapy and the negativity persisted. In contrast, in the non-eradication group HpSA was negative immediately after therapy, but became positive again within 2 wk after the end of therapy, The mean absorbance value of the HpSA test on the 4th day after the initiation of eradication therapy was significantly higher in the noweradication group than in the group with successful eradication. The diagnostic accuracy of the HpSA test increased to〉 90M 2 wk after therapy and thereafter, Comparison of the diagnostic accuracy at 4 wk after the end of therapy showed no significant differences with that at 2, 6, 8, and 12 wk after the end of therapy. The course of the HpSA levels during and after eradication therapy in patients with successful eradication was quite different from that in non-eradication patients. Tt is acident that measuvement of HpSA is useful to evaluate outcome of treatment and the appropriate evaluation should be made as early as 2 wk after the end of therapy.

关 键 词：幽门螺杆菌抗原 幽门螺杆菌 感染 疗效 

分 类 号：R378.2[医药卫生—病原生物学]