生物降解材料聚乳酸－聚乙二醇共聚物体内外降解  

Degradation of Biodegradable Poly (DL-Lactic Acid)and Polyethyleneglycol Block Copolymer In Vivo and In Vitro

作　　者：王定国[1] 胡颖嘉 郑华[1] 吴增树[1] 

机构地区：[1]四川省生物医学材料监测中心

出　　处：《北京生物医学工程》1996年第2期103-107,共5页Beijing Biomedical Engineering

基　　金：国家自然科学基金

摘　　要：本文对ＤＬ－聚乳酸－聚乙二醇共聚物（ＰＥＬＡ）体内外降解进行了研究。采用凝胶渗透色层法（ＧＰＣ）测定分子量，扫描电镜（ＳＥＭ）观察。ＰＥＬＡ在最初第５天出现降解，２月时分子量丧失体内外分别为９７．２８％和９２．０％，而重量仅丧失８％。对其原因进行了讨论，同时将ＰＥＬＡ与ＤＬ－聚乳酸（ＰＬＡ）进行了比较，探讨分析了二者的降解机理。结果表明ＰＥＬＡ是一种新型生物降解材料。The degradation of poly (DL-Lactic acid) and polyethyleneglycol block copolymer (PELA) was monitored in vitro and vivo. PELA degradation was observed in vivo at 5th day with scanning electron mioroscopy (SME), and molecular weight determined by gel permeation chromatography (GPC) showed a reduction to 97% after 8 weeks in vivo and 92% in vitro, whereas the mass loss change was 8% only. The causes were discussed, degradation of DL-PLA was studied in vitro and in vivo and was analyzed. The results showed that PELA is a new biodegradable copolymer.

关 键 词：聚乳酸 体内外降解 PELA 降解 

分 类 号：R318.08[医药卫生—生物医学工程]