10-对硝基苯氧基癸酸合成工艺的改进  

An Improved Synthetic Method of p-Nitrophenoxydecanoic Acid

作　　者：杨建丽[1] 梅乐和[1] 林东强[1] 姚善泾[1] 

机构地区：[1]浙江大学材料与化工学院,浙江杭州310027

出　　处：《江南大学学报（自然科学版）》2006年第2期207-210,共4页Joural of Jiangnan University (Natural Science Edition)　

基　　金：国家自然科学基金项目(20176050);浙江省科技计划项目(2004C33036);浙江省回国人员基金项目;教育部留学回国人员基金项目;中德合作DAAD-CSC研究人员项目(PPP)

摘　　要：对10-对硝基苯氧基癸酸合成工艺进行了改进.以10-溴代癸酸为原料,与甲醇反应生成10-溴代癸酸甲酯,再与对硝基酚钠反应生成10-对硝基苯氧基癸酸甲酯,最后以固定化脂肪酶水解得到10-对硝基苯氧基癸酸.对中间体的折光率和紫外-可见光谱进行分析,并通过紫外-可见光谱1、H-NMR和13C-NMR以及酶分析应用对最终产物进行确证.结果表明,成功合成出目标化合物,总收率达到71.6%.The synthetic method of p-nitrophenoxydecanoic acid was improved in this research. 10 -bromodecanoic acid was reacted with methanol to produce methyl 10-bromodecanoate which was treated with sodium p-nitrophenolate to produce ester, then hydrolyzed with immobilized lipase to obtain p-nitrophenoxydecanoic acid. The characteristic of intermediates were analyzed by refractive index and UV-IV spectrum, The structure of final product was confirmed by UV-VIS, ^1H-NMR, ^13C- NMR and application to enzyme assay, p-Nitrophenoxy.decanoic acid was successfully synthesized by using this method with an yield rate of 71.6%,

关 键 词：10-对硝基苯氧基癸酸 10-溴代癸酸甲酯 合成 工艺 

分 类 号：TQ243.24[化学工程—有机化工] TQ245.12