山楂叶提取物的抗炎与镇痛作用研究  

Anti-inflammation,Analgesic Effects of Extract of Hawthorn Leaf

作　　者：权迎春[1] 关丽萍[1] 

机构地区：[1]延边大学药学院,吉林延吉133000

出　　处：《时珍国医国药》2006年第4期556-557,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的探讨山楂叶乙醇提取物的抗炎、镇痛作用。方法将80只小鼠随机分成4个组,即对照组及山楂叶大、中、小剂量组,山楂叶乙醇提取物灌胃给药,对照组以等体积生理盐水灌胃,采用二甲苯致小鼠耳壳肿胀,测定致炎前后各组小鼠耳厚度之差;观察给予冰醋酸后小鼠的扭体反应及其次数的变化。结果山楂叶乙醇提取物对二甲苯所致小鼠耳壳肿胀有抑制作用,能减少冰醋酸所致小鼠的扭体反应次数,与对照组比较均有显著性差异。结论山楂叶乙醇提取物具有一定的抗炎、镇痛作用。Objective To study the anti - inflammation and analgesic effects of the extract of hawthorn leaf. Methods The 80 mice were randomly divided into control group and small, middle, large dosage groups, and the extract of Hawthorn leaf were given orally. Swelling degrees of ear thickness induced by xylene and number of times of mice twisting body response induced by acetic acid were measured. Results Swelling induced by xylene in the ear of mice was inhibited and frequency of twisting body response induced by ~,cetic acid was reduced with using Hawthorn leaf. There was significant difference between control group and small, middle, large dosage groups. Conclusion Extract of Hawthorn leaf has certain accuse inflammation and analgesic effects.

关 键 词：山楂叶 抗炎 镇痛 提取物 

分 类 号：R285.5[医药卫生—中药学]