复方夏连草胶囊质量标准研究  

Quality Standard for Compound Xialiancao Capsules

作　　者：孙晶[1] 贾晓斌[1] 陈彦[1] 成旭东[1] 李霞[1] 

机构地区：[1]江苏省中医药研究院.江苏省现代中药制剂工程技术研究中心

出　　处：《时珍国医国药》2006年第4期605-606,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的 建立复方夏连草胶囊的质量标准。方法 采用薄层色谱法对黄连、黄芩、炙甘草、佛手进行定性鉴别；并应用高效液相色谱法对其中的盐酸小檗碱进行含量测定。结果 薄层色谱法均能对黄连、黄芩、炙甘草、佛手进行专属定性分析；对盐酸小檗碱在3．056～18．3361μg·ml。（r=0．9999）范围内线性关系良好，平均回收率100．02％，RSD为1．19％。结论 所建立的方法可准确的进行定性、定量检测，能排除其他成分干扰，重复性好，可作为复方夏连草胶囊的质量控制和评价。Objectlve To establish the quality standard for Compound Xialiancao Capsules. Methods Rhizoma Coptidis, Radix Scutellariae, Radix Et Glycyrrhizae Praeparata, Fructus Citri Sarcodactylis in Compound Xialiancao Capsules were identified by TLC ; The content of berberin hydrochloride in the capsules were assayed by HPLC. Results Rhizoma Coptidis, Radix Scutellariae, Radix Et Glycyrrhizae Praeparata, Fructus Cirri Sarcodactylis could be indetified by TLC; Berberin showed a good linear relationship at the range of 3.056-18. 336μg·ml^-1 （r =0. 999 8） ; The average recovery was 100.02% and RSDwas 1.19%. Conclusion The method is accurate and can be used for the quality control of Compound Xialiancao Capsules.

关 键 词：复方夏连草胶囊 薄层色谱 高效液相色谱 盐酸小檗碱 质量标准 

分 类 号：R286.0[医药卫生—中药学]