思瑞康与氯丙嗪治疗精神分裂症的对照研究  

Comparative Study on the Effect of Seroquel and Chlorpromazine on Schizophrenia

作　　者：田慧 何奇 杜玲 吴仁辉 惠述国 郑秋莲 炳映红 

机构地区：[1]湖北襄樊市第一人民医院药剂科,襄樊市441000

出　　处：《中国药房》2006年第9期682-683,共2页China Pharmacy

摘　　要：目的:比较思瑞康和氯丙嗪治疗精神分裂症的疗效和安全性。方法:将92例符合精神分裂症诊断标准(CCMD-3)的患者随机分为2组,每组46例,分别给予思瑞康和氯丙嗪治疗8wk,采用阳性症状与阴性症状量表(PANSS)、不良反应症状量表(TE_SS)评定疗效与不良反应。结果:思瑞康组与氯丙嗪组有效率分别为87.0%、91.3%(P>0.05)。思瑞康组嗜睡、头昏和体质量增加发生率更高(26.1%、23.9%、17.3%),氯丙嗪组锥体外副作用、心动过速和直立性虚脱发生率更高(60.9%、39.1%、32.6%)。结论:思瑞康与氯丙嗪治疗精神分裂症疗效相当,而前者不良反应相对较轻,安全性更好。OBJECTIVE：To compare the efficacy and safety of seroquel and chlorpromazine in the treatment of schizophrenia.METHODS： 92 patients with schizophrenia by CCMD - 3 were rahdornly allocated to 2 groups treated（n = 46） with seroquel or chlorpromazine for 8 weeks, the Positive and Negative Syndrome Scale（PANSS） and Treatment Emergent Side effect Scale（TESS） were used to evaluate efficacy and adverse effect respectively.RESULTS： The significant efficacy rates of seroquel and chlorpromazine were 87.0 %, 91.3% （P〉 0.05） .Seroquel showed high incidence rate of drowsiness, dizziness and weight gain（26.1%, 23.9%, 17.3% ）, chlorpromazine showed high incidence rate of extrapyramidal side effect, pyknocardia and erect collapse（60.9%, 39.1%, 32.6%） .CONCLUSIONS： There was no significant difference of curative effect for the treatment of schizophrenia between seroquel- treated group and chlorpromazine-treated group,but seroque showed low side effect and high safety.

关 键 词：思瑞康 氯丙嗪 精神分裂症 疗效 安全性 对照研究 

分 类 号：R971.4[医药卫生—药品] R969.4[医药卫生—药学]