β纤维蛋白原基因-455G/A多态性与脑梗死的关系研究  

Study of the Relationship Between the Polymorphisms of Gene-455G/A and the Risk of Cerebral Infarction

作　　者：陈森[1] 王爱玲[2] 王长青[2] 余元勋 

机构地区：[1]安徽省蚌埠医学院附属医院,233040 [2]安徽医科大学附属医院 [3]安徽省遗传中心

出　　处：《实用全科医学》2006年第3期253-254,共2页Applied Journal Of General Practice

基　　金：安徽省重点科研项目(编号:2003021007)

摘　　要：目的通过检测脑梗死患者及对照人员的β纤维蛋白原基因-455G/A多态性,探讨该多态性与脑梗死发病的关系,寻找脑梗死发病的遗传性危险因素。方法脑梗死患者40例,对照组4例(排除有冠心病及外周血管血栓疾病者)。利用PCR-RFLP(多聚酶链-限制性片段长度多态性)法检测受试者β纤维蛋白原-455基因多态性,由SPSS11.5软件分析数据。结果①脑梗死组中β纤维蛋白原-455A等位基因频率显著高于对照组;②脑梗死组中β纤维蛋白原-455GA和AA基因型携带者频率显著高于对照组。结论β纤维蛋白原-455A等位基因可能是脑梗死发病的遗传性危险因素。Objectives To analyze the frequency of β - fibrinogen gene - 455 genotypes in cerebral infarction group and contml group. To investigate whether the - 455G/A polymorphisms were associated with the risk of cerebral infarction, To demonstrate the genetic risk of cerebral infarction. Methods Forty patients with cerebral infarction, demonstrated by CT or MAI, and forty control subjects were recruited, The - 455 polymorphisms of β - fibrinogen gene were detected by the methods of PCR - RFLP. Interactions between these changes and other factors were analyzed with SPSS statistical software 11.5. Resuits ① The frequency of - 455A allele were higher in cerebral infarction group than in control group; ② The frequency of - 455AA and GA genotypes were higher in cerebral infarction group than control group, Conclusions β - fibrinogen gene - 455G/A polymorphisms may be a genetic risk factor of cerebral infarction.

关 键 词：脑梗死 β纤维蛋白原基因-455 基因多态性 

分 类 号：R341.41[医药卫生—基础医学] R743.33