65例1型糖尿病肾病患者血C反应蛋白和白介素6的改变  

The C-reactive Protein and Interleukin-6 in 65 Patients with Type 1 Diabetic Nephropathy

作　　者：裴宁[1] 李益明[1] 

机构地区：[1]上海复旦大学华山医院,200031

出　　处：《实用全科医学》2006年第3期265-266,共2页Applied Journal Of General Practice

摘　　要：目的分析1型糖尿病肾病患者血C反应蛋白和白介素6浓度的改变。方法将65例1型糖尿病患者分为无蛋白尿组(n=28)、微量蛋白尿组(n=23)和大量蛋白尿组(n=14)。观测患者血糖、血脂、C反应蛋白(CRP)和白介素6(IL-6)的改变。结果CRP在微量蛋白尿和大量蛋白尿组较无蛋白尿组增高,并与蛋白排泄率有关。IL-6的升高与肾病程度、HDL和蛋白排泄率相关。结论提示1型糖尿病肾病可能伴有体内炎症反应变化。Objective To investigate the changes Of C - reactive protein and interleukin - 6 in 65patients with type 1 diabetic nephropathy. Methods 65 patients with type 1 diabetic were divided into three groups. Normoalbuminuria （ n = 28 ）, microalburninuria（ n = 23） and macroalbuminuria （ n = 14）. Results C- reactive protein （CRP） was associated with albumin excretion rate （AER）. And it was higher in micro - and macroalbuminuric patients compared to normoalbuminuria. HDL - cholesterol and duration of diabetes were independently associated with interleukin - 6. Conclusions CRP and interlukin - 6 are corelation with the diabetic nephropathy in type 1 diabetes. The predictive value needs to be assessed.

关 键 词：1型糖尿病 糖尿病肾病 C反应蛋白 白介素6 

分 类 号：R587.24[医药卫生—内分泌] R446.11[医药卫生—内科学]