姜黄素衍生物药理活性的研究进展  

Progress in Study of Pharmacological Activity of Curcumin Derivatives

作　　者：张晓光[1] 许建华[1] 

机构地区：[1]福建医科大学,福州350004

出　　处：《世界科学技术-中医药现代化》2006年第2期78-82,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金项目(30472187)姜黄素对慢性白血病细胞P210蛋白伴侣HSP90结合的影响与逆转慢粒白血病细胞耐药性的研究;;福建医科大学2005校级科学研究发展基金重点项目(XZ04007)姜黄素衍生物的合成与抗癌活性研究

摘　　要：姜黄(Curcuma longa L．)为姜科姜黄属植物,药用其根茎,主产于中国、印度、日本等国家。1870年从姜黄属植物中分离出姜黄素,1910年Lampe等首先阐明了其化学结构。现已证明其具有抗肿瘤、抑炎、利胆、抗氧化、抗肝细胞毒性、抗风湿、抑菌、抗低血压、低胆固醇等广泛的药理作用。目前对其化学结构进行修饰已成为国内外研究的热点。本文就目前对姜黄素衍生物的研究进展做一综述。Curcuma longa L. is a plant of Zingiberaceae and Curcuma genus, which grow India and Japan, and its root is used as medicine. In 1870 curcumin was separated mainly in such countries as China, from the plants of Curcuma genus and in 1910 Lampe and other scholars first expounded its chemical construction.It is proved that curcumin has extensive pharmacological functions, such as anti -tumor, anti -inflamination, anti -oxidation, anti -hapatoxin, anti -rheumatism, bacteriostasis, anti-hypotension and the reduction of cholesteral. At present studies are focused on the modification of its chemical construction at home and abroad. This article summarizes the progress of the present studies in curcumin derivatives.

关 键 词：姜黄素衍生物 药理活性 机制 化学结构 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]