2004年天津市2～17岁人群百日咳、白喉抗体水平监测分析  

Analysis on monitoring for antibody level of pertussis and diphtheria among people aged 2 to 17 years in Tianjin City in 2004

作　　者：陈伟[1] 万丽霞[1] 井良义[1] 高志刚[1] 

机构地区：[1]天津市卫生防病中心,天津300011

出　　处：《疾病监测》2006年第3期123-124,共2页Disease Surveillance

摘　　要：目的了解天津市百日咳、白喉高危人群免疫水平。方法随机抽取2-17岁8个年龄组的儿童采集有效血样1103份,白喉抗毒素用间接血凝法(IHA)测定,百日咳抗体用微量凝集试验测定,并用 SPSS 11．5对监测结果进行统计学分析。结果 2～17岁的健康人群百日咳凝集抗体阳性率为65．29%,保护率为38．17%,抗体阳性率和 GMT 随年龄的增长而显著下降；白喉抗体保护率均在80．00%以上,平均抗体保护率为87．98%,平均抗毒素为0．12IU/ml,不同年龄组之间抗体保护率及平均抗毒素差异均有统计学意义。结论在继续做好健康人群免疫水平监测的同时,应注重百日咳、白喉的加强免疫工作。Objective This study was conducted to understand the immunity in the high-risk population of pertussis and diphteria in Tianjin City. Methods Eight age groups of children aged 2 to 17 years were sampled at random, and 1103 effective blood samples were taken. The diphteric antitoxin was determined with indirect hemaglutination （IHA）, while the antibody of pertussis with micro agglutination test, and at the same time, a statistical analysis for the monitoring results was done with SPSS 11.5. Results Among healthy people aged 2 to 17 years, the positive rate of antibody for pertussis measured with micro agglutination test was 65.29%, and protective rate 38.17%. The positive rate of antibody and GMRT decreased significantly with increase of age. The protective rates for antibody of diphtheria were all above 80.00%, and averaged 87.98%, with average antitoxin 0.12 IU/ml. The protective rate for antibody and average antitoxin all showed a significant difference among age groups. Conclusion Further immunization work for pertussis and diphtheria should be emphasized at the same time that immunity monitoring among healthy people is continued.

关 键 词：百日咳 白喉 抗体监测 

分 类 号：R186[医药卫生—流行病学]