梅毒血清固定患者细胞免疫功能研究  

Cellular Immunity in Patients With Sero-resistance of Syphilis

作　　者：包图雅[1] 于娜沙[1] 曾抗[1] 李莉[1] 方亮[1] 

机构地区：[1]广州南方医科大学附属南方医院皮肤性病科,广东广州510515

出　　处：《实用预防医学》2006年第2期254-255,共2页Practical Preventive Medicine

摘　　要：目的研究血清固定梅毒患者系统细胞免疫功能的变化,以探讨细胞免疫功能对梅毒血清固定的影响。方法应用流式细胞仪对38例血清固定梅毒患者及23例健康人外周血T淋巴细胞亚群及NK细胞检测,并检测结果相对照。结果血清固定梅毒患者外周血CD3+、CD8+、Th2与健康组相比差异无显著性(P>0.05),CD4+、Th1、Tc、NK低于健康组,差异有显著性(P<0.01),Ts细胞明显高于健康组,差异有显著性(P<0.01)。结论梅毒血清固定患者存在细胞免疫功能低下,免疫受抑制,细胞免疫功能低下在梅毒患者血清固定病程中起着一定的作用。Objective To study the changes of systemic cellular immunity in patients with sero- resistance of syphilis and to their mechanisms, Methods T lymphocyte subsets and NK cell were measured by flow cytometry in peripheral blood of 38 sero- resistance and 23 healthy subjects. Results The CD3^＋ , CD8^＋ and Th2 showed no obvious differences between sero-resistance group and the healthy control group（P 〉0.05）; but CD4^＋ , Th1 Tc and NK cells in patients were lower than in healthy controls（P〈 0.01 ）. Ts in patients were higher than in the healthy controls（P〈 0.01 ）. Conclusions Patients with sero- resistance of syphilis have low cell- mediated immunity, which might play an important role in the pathogenesis of serofastness of the patients.

关 键 词：梅毒 血清固定 T淋巴细胞亚群 流式细胞仪 免疫功能 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]