胎儿生长迟缓与新生儿胰岛素敏感性变化的相关性  

A study on the association between fetal growth retardation and the change of insulin sensitivity in the neonates

作　　者：刘占利[1] 梁琨[1] 贺湘英[1] 朱高红[2] 王柏岺 曾彬[1] 莫亚雄[1] 

机构地区：[1]昆明医学院第一附属医院儿科,云南昆明650032 [2]昆明医学院第一附属医院核医学科,云南昆明650032

出　　处：《中国实用儿科杂志》2006年第5期357-359,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的 探讨胎儿生长迟缓（FGR）与新生儿胰岛素敏感性变化的关系。方法 昆明医学院第一附属医院于2004年4-12月。对72例小于胎龄儿（SGA）和48例适于胎龄儿（AGA）空腹血糖（FPG）、空腹胰岛素（FINS）、C-肽、HDL-C、LDL-C、TG、非酯化脂肪酸（NEFA）等指标，计算葡萄糖／胰岛素比值（G／1）、胰岛素敏感性指数（ISI）、胰岛素抵抗指数（HOMA-IR）、胰岛B细胞功能（HBCI）等，探讨FGR与新生儿胰岛素敏感性变化的关系。结果 （1）SGA组FPG、HDL-C低于AGA组，而FINS、LDL．C、TG、NEFA高于AGA组（P〈0．01）；（2）SGA组G／I比值、ISI低于AGA组。HOMA-IR高于AGA组（P〈0．01），而HBCI两组相比差异．无显著性（P〉0．05）。结论 FGR儿在生命早期存在胰岛素敏感性降低和不同程度的胰岛素抵抗（IR），而胰岛B细胞功能无明显变化。Objective To explore the relationship between fetal growth retardation（ FGR）and the change of insulin sensitivity in neonates. Methods From April 2004 to December 2004,72 small for gestational age infants （ SGA ） and 48 appropriate-for-gestational-age infants（ AGA）were selected in the present study in the First Affiliated Hospital of Kunming Medical College. Fasting plasma glucose （ FPG ）, fasting insulin （ FINS ）, high density lipoprotein-cholesterol （ HDL-C ） ,low density lipoprotein-cholestero（ LDL-C ） ,triglyceride （ TG ） and non-esterified fatty acids （ NEFA ） were assayed; glucose/ insulin ratio （ G/I） ,insulin sensitivity index（ ISI） ,insulin resistance index（ HOMA-IR） , the function of β-cell of pancreatic islands （ HCBI ）, etc. were calculated. Explore the relationship between FGR and the change of insulin sensitivity in neonates. Results The level of FPG and HDL-C in SGA group was lower than that in AGA group,but the level of FINS, LDL-C,TG and NEFA was higher（ P 〈0. 01 ）. G/I ratio,ISI in SGA group were lower than that in AGA group. HOMAIR was higher（ P 〈 0. 01 ）. However, there was no significant difference in HBCI between two groups. Conclusion In early postnatal life FGR neonates display decreased insulin sensitivity and insulin resistance （ IR ） to some extent. Howev- er,the function of β-cell of pancreatic islands has no remarkabe change.

关 键 词：胎儿生长迟缓 小于胎龄儿 适于胎龄儿 胰岛素敏感性 胰岛素抵抗 

分 类 号：R72[医药卫生—儿科]