2型糖尿病合并冠心病患者微量蛋白尿检测的临床意义  

作　　者：李文华[1] 张祖煌[1] 宫建丽[1] 孔香云[1] 张秀州[1] 唐元升[1] 朱兴雷[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《山东医药》2006年第13期16-18,共3页Shandong Medical Journal

基　　金：山东省卫生科技发展计划(200335)

摘　　要：目的探讨2型糖尿病合并冠心病患者微量蛋白尿检测的临床意义。方法按照微量蛋白尿分组,对184例2型糖尿病合并冠心病患者的临床资料及冠状动脉造影(CAG)结果进行对照分析。结果与微量蛋白尿阴性组相比,微量蛋白尿阳性组患者具有高龄、高血压、高体重指数、高血糖、高甘油三酯、高低密度脂蛋白胆固醇等心血管危险因素,且CAG单支血管病变少,多支血管及弥漫性病变多,血管狭窄程度重,左室射血分数低,心肌梗死和心力衰竭的发生率高。结论微量蛋白尿检测可作为早期预测2型糖尿病合并冠心病患者冠状动脉病变的指标之一。微量蛋白尿阳性的2型糖尿病合并冠心病患者冠状动脉广泛、弥漫且严重。Objective： To study the clinical value of mieroalbuminuria testing in type 2 diabetes mellitus patients with coronary heart disease （CHD）. Methods： The study was carried out by control analysis of clinical manifestations and data from selective coronary angiography of 184 cases type 2 diabetes mellitus patients with CHD between different groups divided by microatb uminuria levels. Results： Compared with microalbuminuria - negative patients, microalbuminuria -positive type 2 diabetes mellitus patients with CHD tended to gather more various risk factors such as older age, hypertension, larger body mass index （BMI）, higher blood sugar （BS）, highertriglyceride （TG） and higher low density lipoprotein cholesterol （LDL-C） level. Coronary angiography results suggested they had less single vascular lesions, more multi-vascular lesions and more diffuse lesions, higher narrow degree of involved vessels and lower left ventrieular election fraction （LVEF）. They also had a higher incidence of myoinfarction and heart failure. Conclusions： Microalbuminuria testing can be used as an index to evaluate the coronary artery lesions in type 2 diabetes mellitus patients with CHD. Positive microalbuminuria suggests the lesion is more widespread, diffuse and severe.

关 键 词：冠状动脉疾病 冠状动脉造影术 微量蛋白尿 左室射血分数 2型糖尿病 冠心病 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]