用外周血单核细胞衍生的树突状细胞评价抗组胺药治疗慢性荨麻疹的药效  

Evaluation of the Efficacy of Antihistamines in the Treatment of Chronic Urticaria Using Human Monocyte-derived Dendritic Cells

作　　者：张彩萍[1] 崔盘根[1] 

机构地区：[1]中国医学科学院,中国协和医科大学皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2006年第3期176-178,共3页International Journal of Dermatology and Venereology

摘　　要：慢性荨麻疹是皮肤科常见病之一,病因不明,易诊难治。抗组胺药为治疗此类疾病的首选药物,但对部分患者疗效不十分肯定,如何评价药物的有效性尚缺乏客观指标。概述了树突状细胞在变应性疾病中的功能及用体外培养外周血单核细胞衍生的树突状细胞评价抗组胺药药效的实验进展,以期为评估抗组胺药治疗慢性荨麻疹的药效提供依据。Chronic urticaria is a very common skin disease. It is easy to diagnose but difficult to treat. Antihistamines are the drugs of first choice, however, some patients show indefinite responses to them. There is still no objective index to assess the efficacy of antihistamines. We review the function of dendritic cells in allergic diseases and the progress in experiments evaluating the efficacy of antihistamines by human monocyte-derived dendritic cells, to provide a platform for evaluating the efficacy of antihistamines in the treatment of chronic urticaria.

关 键 词：荨麻疹 组胺H1拮抗剂 树突细胞 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]