光纤化学传感快速测定复方氯唑沙宗片两组分含量  

The real-time FOCS detection method and conditions for concentration test of Compound Chlorzoxazone Tablets

作　　者：吴军[1] 李新霞[2] 陈坚[2] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830054 [2]新疆医科大学药学院,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2006年第4期286-288,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区高技术发展计划资助项目(200311110)

摘　　要：目的:建立光纤化学传感技术快速监测固体复方制剂两组分含量的测定方法。方法:分支光纤一端连接光源,公共端部探头浸入溶出液,另一端连接检测器,计算机记录并处理数据。结果:复方氯唑沙宗片中对乙酰氨基酚的高、中、低浓度组回收率分别为98．3％、102．3％、103．1％;RSD分别为1．0％、1．4％、0．4％;氯唑沙宗的高、中、低浓度组回收率分别为108．6％、98．7％、97．7％;RSD分别为1．7％、1．6％、1．3％。本法可在线快速监测药物两组分含量。结论:光纤化学传感技术能够有效地测定固体药物两组分的含量,可为药品质量的控制提供技术支持。Objective： To study a method which can monitor the concentration of drug quickly-Fiber optic chemical sensor （FOCS）. Methods： Bifurcated optical fiber was used to connect light source and detector and the common end was dipped in the solutims vessel. The procession could be monitored through computer. Result. The high, middle and low Concentration groupls recovery of Paracetamol is 98. 3%,102.3%, 103.1% RSD is 1.0%, 1.4%, 0.4% respectively; The high, middle and low Concentration 1 group s recovery of Chlorzoxazone is 108.6%, 98.7%, 97.7% ; RSD is 1.7%, 1.6%, 1.3% respectively.Orocession analysis can test the whole process of drug . Conclution. This procession analysis can reflect the real concentration of drug and support for contrdling mass of drug.

关 键 词：光纤化学传感 复方氯唑沙宗片 含量 

分 类 号：R962[医药卫生—药理学] R965.2[医药卫生—药学]