SARS冠状病毒核衣壳蛋白的研究进展  

The Advance on the Nucleocapsid Protein of SARS-CoV

作　　者：刘俊丽[1] 曹诚[1] 马清钧[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100850

出　　处：《生物技术通讯》2006年第2期238-241,共4页Letters in Biotechnology

摘　　要：核衣壳蛋白(N蛋白)是SARS冠状病毒(SARS-CoV)的结构蛋白,与病毒RNA结合形成核衣壳,是主要的抗原分子。最近的亚定位研究表明,它主要定位到细胞质,核仁内也有较少的分布。SARS-CoVN蛋白参与SARS-CoVRNA合成的调控以及核衣壳的形成,并能结合人亲环素(hCypA)解离病毒核心,激活AP-1信号转导途径,类泛素蛋白化干扰宿主细胞分裂,在缺乏生长因子的情况下诱导细胞凋亡。Nucleocapsid protein （N protein） is a structural protein of SARS-CoV, which is known to bind viral RNA to form the helical nucleocapsid. Nucleocapsid protein of SARS-CoV is highly immunogenic. Recent studies about its sublocalization indicates that it was largely distributed in the cytoplasm, and to a significant less extent in the nucleolus. Nucleocapsid protein of SARS-CoV was shown to play important roles such as regulation of SARS-CoV RNA synthesis and nucleocapsid formation, disassembly of the viral core by binding to human cyclophilin A to, activation of AP-1 signal transduction pathway, interference of host cell division by sumoylation of SARS N protein and inducing apoptosis in Cos-1 cells in the absence growth factors reviewed briefly in this article.

关 键 词：SARS冠状病毒 核衣壳蛋白 亚定位 生物学功能 

分 类 号：R373.1[医药卫生—病原生物学]