乌司他丁对重度脓毒症患者淋巴细胞亚群的影响  

The changes of lymphocyte subsets in patients with severe sepsis and the effect of Ulinastatin

作　　者：邢金燕[1] 韩小宁[1] 孙运波[1] 栾敏[1] 杜春艳[1] 

机构地区：[1]青岛大学医学院附属医院ICU,山东省青岛266003

出　　处：《中华急诊医学杂志》2006年第5期441-443,共3页Chinese Journal of Emergency Medicine

摘　　要：目的探讨乌司他丁对重度脓毒症患者淋巴细胞计数及各亚群比例变化的影响。方法观察重度脓毒症患者的APECHEⅡ评分及SOEA评分,以及淋巴细胞计数和各亚群细胞比例的变化情况。结果经治疗患者较高的APECHEⅡ评分及SOEA评分水平降低,淋巴细胞计数回升,比例改善,以乌司他丁组改善更明显。革兰氏阳性细菌感染患者表现出更明显而持久的淋巴细胞亚群改变。结论重度脓毒症患者淋巴细胞计数下降且各亚群比例异常,乌司他丁有助于纠正该异常。Objective To investigate the effects of ulinastatin on the number of peripheral blood lymphocyte and the percentage of its subsets in patients with severe sepsis. Methods The scores of APECHE Ⅱ and SOFA, the number of lymphocyte and the percentage of different subsets in these sepsis patients at different treatment time were measured. Results After treatment, the scores of APECHE Ⅱand SOFA of severe sepsis patients were decreased, the number of lymphocyte elevated and the percentages of different subset were eorrceted. Sepsis eansed by Gram - positive pathogens had stronger suppression of peripheral blood lymphocyte and subsets compared with Gram - negative pathogens, Conclusion Patients with severe sepsis had less peripheral blood lymphocyte and abnormal subsets. Ulinastatin could help to correct such abnormality.

关 键 词：重度脓毒症 淋巴细胞 淋巴细胞亚群 乌司他丁 免疫 

分 类 号：R631[医药卫生—外科学]