β-D-葡萄糖基硫脲合成及生物活性研究  

Synthesis of β-D-Glucopyranosyl Thiourea and Biological Activity

作　　者：王小明[1] 朱涛[2] 郑良玉[3] 李耀先[1] 张锁秦[1] 白杰[1] 

机构地区：[1]吉林大学化学学院,长春130023 [2]吉林大学超分子结构与材料教育部重点实验室,长春130012 [3]吉林大学分子酶学工程教育部重点实验室,长春130023

出　　处：《有机化学》2006年第5期660-666,共7页Chinese Journal of Organic Chemistry

摘　　要：从1-溴-2,3,4,6-四乙酰化-β-D-吡喃葡萄糖(I)出发,经异硫氰酸酯化反应,合成了2,3,4,6-四乙酰化-β-D-吡喃糖基硫脲化合物IV,再经脱乙酰化得到V.将乙酰化糖基异硫氰酸酯的合成从文献的60%提高到80%.所得化合物经元素分析,IR,MS,1HNMR和13CNMR谱学分析确定了结构,并对产物进行了初步的除草活性测试.2,3,4,6-Tetra-acetyl-β-D-glucopyranosyl thioureas Ⅳ were synthesized by the reaction of aniline with 2,3,4,6-tetra-acetyl-β-D-glucopyranosyl isothiocyanate generated from 1-bromo-2,3,4,6-tetra-acetyl-α- D-glucopyranuronate and KSCN in reflux acetonityile. In the synthesis of acetyl-β-D-glucopyranosyl isothiocyanate, the yield was raised from 60% to 80%. The structures of the compounds were confirmed by IR, MS, NMR spectra and elemental analysis. The preliminary biological tests indicate that some compouds of Ⅳ and Ⅴ show good herbicidal activity.

关 键 词：糖基硫脲 合成 生物活性 

分 类 号：TQ463.2[化学工程—制药化工]