多氟烷基取代的环丙烷衍生物的合成  

Synthesis of Polyfluoroalkyl Substituted Cyclopropane Derivatives

作　　者：吴范宏[1] 顾松[1] 黄维垣[2] 

机构地区：[1]华东理工大学化学与制药学院,上海200237 [2]中国科学院上海有机化学研究所有机氟化学开放实验室,上海200032

出　　处：《有机化学》2006年第5期671-675,共5页Chinese Journal of Organic Chemistry

摘　　要：以连二亚硫酸钠为引发剂,烯丙基丙二酸二乙酯与多氟烷基碘代烷在温和条件下反应,方便地得到一系列多氟烷基取代的环丙烷衍生物,产率45%～55%.在相同条件下,烯丙基乙酰乙酸乙酯与多氟烷基碘代烷反应得到相应的加成物,加成物随后用碱处理也得到环合的产物.A new convenient synthesis of a series of polyfluoroalkyl substituted cyclopropane derivatives was achieved by the reaction of polyfluoroalkyl iodides with diethyl allylmalonate in the presence of sodium dithionite in 45%-55% yields. The reaction of ethyl allylacetoacetate with polyfluoroalkyl iodides under similar conditions gave the corresponding adducts, which were sequentially treated with base to the cyclization products.

关 键 词：多氟烷基碘代烷 环丙烷衍生物 连二亚硫酸钠 

分 类 号：O623.1[理学—有机化学]