A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindolines via AIEt3-promoted Tandem Reductive Rearrangement of α-Hydroxy Epoxides  

作　　者：高栓虎 贾彦兴 赵学智 涂永强 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2006年第5期595-597,共3页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos, 29525205, 30271488, 20021001 and 203900501 ）.

摘　　要：The fully substituted cyclopentenedione core of madindoline A （1） and B （2） as potent and selective inhibitor of IL-6 has been synthesized efficiently. The quaternary carbon center C-2＇ was constructed on the basis of a newly developed AIEt3-promoted tandem reductive rearrangement of α-hydroxy epoxides.The fully substituted cyclopentenedione core of madindoline A （1） and B （2） as potent and selective inhibitor of IL-6 has been synthesized efficiently. The quaternary carbon center C-2＇ was constructed on the basis of a newly developed AIEt3-promoted tandem reductive rearrangement of α-hydroxy epoxides.

关 键 词：madindoline total synthesis tandem reaction quaternary carbon epoxide rearrangement 

分 类 号：O624.42[理学—有机化学]