2型糖尿病患者并发外周动脉疾病的危险因素  

Risk factors of peripheral artery disease in patients with type 2 diabetes mellitus

作　　者：侯建明[1] 林庆明[1] 庄维特[1] 林丽香[1] 

机构地区：[1]福建省立医院内分泌科福建医科大学省立临床学院,福州350001

出　　处：《中国医师进修杂志（内科版）》2006年第5期14-16,19,共4页Chinese Journal of Postgraduates of Medicine

基　　金：福建省自然科学基金计划资助项目(C0410041)

摘　　要：目的 分析外周动脉疾病（RAD）在伴有危险因素的2型糖尿病（T2DM）患者中的发病率及PAD的危险因素。方法 401例T2DM患者中，男201例，女200例，平均年龄（63．4±8．8）岁，双下肢任一侧踝肱指数（ABI）≤0．9诊断为PAD。结果 T2DM患者PAD发病率为19．4％，性别差异无统计学意义。单变量分析提示年龄、高血压、收缩压、低密度脂蛋白-胆固醇和（T2DM）病程为其危险因素，多因素Logistic回归分析提示年龄、收缩压、低密度脂蛋白-胆固醇和T2DM病程为其独立危险因素。各自OR值及95％可信限（CI）分别为：年龄1．94（1．20～2．60）。收缩压1．12（0．88-1．43），低密度脂蛋白-胆固醇1．32（0．97～1．63），T2DM病程1．27（0．96～1．73）。结论 T2DM患者PAD发病率约为19．4％，其主要危险因素是年龄、收缩压、低密度脂蛋白-胆固醇和T2DM病程。这提示尽早良好控制血压、血脂和血糖对延缓或阻止PAD发生非常重要。Objective To evaluate the prevalence and risk factors of peripheral arterial obstructive disease （PAD） in type 2 diabetes mellitus（T2DM） patients. Methods A total of 401 patients with T2DM （201 men and 200 women）,mean aged was（63.4 ＋ 8.8）years. PAD was diagnosed by an ankle- brachial index （ABI）≤0.9 on either leg. Results Overall prevalence of PAD was 19.4%, without significant sexual difference. Univariate analyses disclosed age, hypertension, systolic blood pressure （SBP）, low dense lipoprotein cholesterol（LDL- C） and T2DM duration as significant risk factors. In multiple Logistic regression, age, SBP, LDL- C and T2DM duration were independent risk factors with respective odds ratios （95% confidence intervals, CI） of 1.94（1.20 - 2.60）, 1.12（0.88 -1.43）, 1.32（0.97-1.63） and 1.27（0.96-1.73） respectively. Conclusions Prevalence of PAD in T2DM patients is 19.4 % and the major risk factors were older age, higher SBP, higher LDL- C and T2DM duration. This implies that it is very important to prevent the incidence of PAD for better glucose, lipid and blood pressure control early.

关 键 词：糖尿病 外周动脉疾病 踝肱指数 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]