胰岛素抵抗与高血压及其血压严重程度的相关性研究  

Study on the correlation between insulin resistance and severity of hyperension

作　　者：孟秋云[1] 陈燕[1] 李桂英[1] 

机构地区：[1]山东省泰安市第四人民医院内科,271000

出　　处：《临床内科杂志》2006年第5期337-339,共3页Journal of Clinical Internal Medicine

摘　　要：目的探讨胰岛素抵抗与高血压及其血压严重程度的关系。方法选择177例正常人和166例高血压病非糖尿病患者。所有患者均抽血查胰岛素、糖耐量试验(OGTT),以胰岛素敏感指数(ISI)及胰岛素曲线下面积(IS-AUC)作为胰岛素敏感性的判定指标。并据SBP≥160mmHg和(或)DBP≥100mmHg将高血压病组分为两组。用多元相关分析及多因素逐步回归分析胰岛素抵抗与高血压的相关性。结果高血压病组的年龄、体重指数、ISI、IS-AUC与对照组比较有显著差异(P<0.05)。高血压病两组间比较ISI、IS-AUC有显著差异(P<0.05)。经相关分析显示ISI、IS-AUC与血压升高有显著相关性,ISI与血压升高呈显著负相关,IS-AUC与血压升高呈显著正相关。多因素逐步回归分析显示ISI、IS-AUC是血压升高的最显著危险因子。结论胰岛素抵抗与高血压及其血压严重程度相关,胰岛素抵抗是血压升高的最重要的影响因素,胰岛素敏感性越低,血压越高。Objective To investigate the relationship between insulin resistance （IR） and severity of hypertension in hypertensive patients. Methods 177 normal controls and 166 hypertensive non-diabetics received the plasma insulin（IS） ;Glucose tolerance test（OGTT）. Insulin sensitivity index（ISI） and the area under insulin curve（Insulin-Auc） were taken as the index of insulin sensitivity. 166 hypertensive patients were divided into two groups based on SBP≥160mmHg and（or） DBP≥ 100mmHg. The relationship between IR and hypertension was nanlyzed by Multiple correlation analysis and stepwise regression. Results Age;Body mass index （BMI）;ISI; IS-AUC were significant difference between EH group and control group. ISI（ absolute value） and IS-AUC were significantly difference between two EH groups. Multiple correlation analysis showed that ISI and IS-AUC were correlated with elevation of blood pressure ,Elevation of blood pressure was positively related to IS-AUC and negatively related to ISI. Multiple stepwise regression showed that significant risk factors for elevating of blood pressure were ISI and IS-AUC. Coulusions IR was correlated with hypertension and severity of hypertension. IR was significant risk factor for elevating of blood pressure. The more the index of insulin sensitivity was lower, The more blood pressure was hie.her.

关 键 词：高血压 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]