不同透析方法对透析病者血浆脂蛋白和载脂蛋白的影响  

THE CHANGES OF LIPIDS,LIPOPROTEINS ANDAPOLIPOPROTEINS IN THE PATIENTSUNDERGOING DIFFERENTDIALYSIS METHODS

作　　者：余学清[1] 沈清端[1] 李惠群[1] 董秀清[1] 

机构地区：[1]中山医科大学肾脏研究所

出　　处：《中山医科大学学报》1996年第2期120-125,共6页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：观察５９例维持性血液透析（ＭＨＤ）、３６例持续性非卧床性腹膜透析（ＣＡＰＤ）病者透析前后血脂、脂蛋白及载脂蛋白的变化。结果显示，ＭＨＤ病者透析后血甘油三脂（ＴＧ）、极低密度脂蛋白胆固醇（ＶＬＤＬ－Ｃ）轻度升高，载脂蛋白Ｂ－１００（ａｐｏＢ－１００）明显升高，总胆固醇（ＴＣ）、ａｐｏＡＩ、ａｐｏＡⅡ、ａｐｏＣⅡ及ａｐｏＣⅡ／ａｐｏＣⅢ均明显降低；ＣＡＰＤ病者治疗后ＴＧ、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、ＶＬＤＬ－Ｃ、ａｐｏＢ－１００、ａｐｏＣⅢ较透析治疗前明显升高，而ａｐｏＡⅠ明显降低；有动脉硬化合并症的透析患者，其脂质代谢紊乱明显重于无动脉硬化的患者。上述事实表明，透析病者有明显的脂质代谢紊乱，ＣＨＤ和ＣＡＰＤ对透析病者脂质代谢的影响有不同，且两者均存在加速和对抗动脉硬化因子的失衡，有明显的促进动脉硬化的倾向。In order to understand the lipid metabolism in patients receiving dialysis , the plasma lipid , lipoproteins and apolipoproteins of 59 patients with maintain hemodialysis and 36 with CAPD were measured. The results showed that TG , VLDL-C and were lightly increased , apo B100 was markedly increased in the patients undergoing hemodialysis , whereas TC , apo AⅠ , apoAⅡ , apoCⅡ , apoCⅡ/apoCⅢwere decreased. In patients withCAPD, raised TG , LDL-C , LDL-C apo B-100 , apoCⅢ and reduced apo AⅠ were observed. Meanwhile , the authers also found the different level of lipids, liproteins , apolipoproteins in the patients with and without arterosclerosis. All data suggested that there were markedly lipid metabolism deturbance in patients receving hemodialysis and CAPD. The imbalance between anti- and accelerated arterosclerosis factors may be the main cause inducing atherosclerosis.

关 键 词：脂蛋白 载脂蛋白 血液 血液透析 腹膜透析 

分 类 号：R692.505[医药卫生—泌尿科学] R459.5[医药卫生—外科学]