糖皮质激素和肠道残留钡剂对骨密度的影响  

High-dose glucocorticoids and remaining barium in the small intestine affecting bone mineral density

作　　者：王波[1] 汪淑娟[2] 张全[2] 徐滨[2] 

机构地区：[1]解放军总医院器械处,北京100853 [2]解放军总医院妇产科,北京100853

出　　处：《中国骨质疏松杂志》2006年第2期157-158,127,共3页Chinese Journal of Osteoporosis

摘　　要：目的探讨了大剂量糖皮质激素和肠道残留钡剂对女性患者骨密度的影响。方法用双能X线骨密度仪测量14例使用大剂量糖皮质激素的女患者和2例肠道残留钡剂女患者。结果14例妇女经大剂量糖皮质激素治疗一个月,累计剂量达1000mg左右,均出现闭经,其中10例患者持续闭经四个月,骨密度值呈下降趋势。4例患者停药后月经恢复,骨密度值呈上升趋势,但尚未达到统计学意义。肠道残留钡剂在骨密度仪荧光屏出现明显的亮度,应停止骨密度测量。结论大剂量糖皮质激素使妇女骨密度值下降。肠道残留钡剂影响骨密度测定,结果失去真实性。Objective To observe the bone mineral density（BMD） of the high-dose glucocorticoids used for treating female patients and remaining barium in the small intestine of female patients. Method The patient＇s BMD were determined with DEXA（DPX-L）. Results 14 female patients were treated by high-dose glucocorticoids for one month,total amount almost 1000 ± 110 mg, when they occured the amenorrhoea, 10 of 14 female patients keeping up a steadly the amenorrhoea, for 4 momths, their BMD was a fall. Another 4 recovering menstruation after using high-dose glucocorticoids for one month, their BMD was a slightly rise. Remaining barium in the small intestine,the obviously light appeared on the fluorescent screen and examining should be stop. Conclusions Female patient＇s BMD appeared a fall, using high-dose glucocorticoids for treating. The real value of BMD lost when remaining barium in the small intestine.

关 键 词：糖皮质激素 骨密度 钡剂 

分 类 号：R977.1[医药卫生—药品] R681[医药卫生—药学]