中药对绝经妇女股骨颈骨密度及股骨颈抗骨折能力的影响  

Effects of traditional Chinese medicine on bone mineral density and femoral neck strength in postmenopausal women

作　　者：阮祥燕[1] 齐久梅[1] 刘玉兰[1] 季颖[1] 陈宝英[1] 

机构地区：[1]首都医科大学附属北京妇产医院内分泌诊疗中心,北京100026

出　　处：《中国骨质疏松杂志》2006年第2期181-184,共4页Chinese Journal of Osteoporosis

基　　金：北京市中药局课题经费资助项目(2001);首都医学发展基金资助项目(20022038)

摘　　要：目的观察中药强骨胶囊(QGJN)对绝经妇女股骨颈骨密度(BMD)及股骨颈抗骨折能力(FS)的影响。方法择自愿参加研究的绝经1年以上,年龄60岁以下的骨量减少或骨质疏松的绝经妇女150例,随机分为3组:中药+激素组(50例):采用中药QGJN联合雌激素戊酸雌二醇治疗;中药组(50例):单纯用中药QGJN治疗;激素组(50例):单纯用雌激素戊酸雌二醇周期序贯治疗;另50例符合上述条件,目前不愿接受研究用药的绝经妇女作为对照组。各组均于治疗前及治疗后24w采用DEXA骨密度仪测定股骨颈(BMD),采用肌肉功能分析仪测定股骨颈抗骨折能力(FS)。结果因各种原因失访18例,182例(包括对照组)完成了总疗程。中药+激素组(46例)、中药组(48例)、激素组(42例)、股骨颈BMD及FS较治疗前均有明显升高,增幅分别为7.33%、9.04%(P<0.01);3.38%,5.87%(P<0.01);3.57%,5.91%(P<0.01),其中中药+激素组BMD及FS升高幅值均明显高于中药组(P<0.01)和激素组(P<0.01);而激素组上述指标较中药组略高,但差异无显著性(P>0.05);对照组(46例)的BMD及FS明显下降,下降幅值分别为3.30%、5.31%,P<0.01)。结论中药强骨胶囊能提高绝经妇女股骨颈骨密度及股骨颈抗骨折能力。从而对绝经妇女骨质疏松具有较好的防治作用,其效果与雌激素戊酸雌二醇相仿,两药联用效果更好。Objective To observe the effect of traditional Chinese medicine QIANGGU JIAONANG（QGJN） on bone mineral density （BMD） and femoral neck strength in postmenopausal women. Methods Totally, 200 menopausal women, aged ≤ 60 and being menopaused over 1 year with bone loss or osteoporosis, were enrolled. All women were divided into 4 groups （50 in each） ：Group A were treated with QGJN and oral estradiol valerate; Group B were managed with QGJN only; Group C with oral estradiol valerate only; Group D as control. Bone mineral density of femoral neck was measured with DEXA and femoral neck strength with Muscle Evaluation System （MES） before and 24 weeks after the treatment.Results Totally, 182 women completed the trial including 46 in group A, 48 in group B, 42 in group C and the rest in group D. The BMD and FS in group A, B, C were significantly increased after the treatment （7.33% vs 9.04%; 3.385 vs 5.87% ; 3.57% vs 5.91%, P 〈 0.01） with more increase in group A than that of group B and C （ P 〈 0.01 ） and more in group C than that of B（ P 〈 0.01）. Significant decrease of BMD and FS was detected in group D （3.30% and 5.31%, P 〈 0.01 ）. Conclusions Traditional Chinese medicine （QGJN） can improve the BMD and FS in menopausal women.

关 键 词：股骨颈骨密度 股骨颈抗骨折能力 绝经后骨量减少 绝经后骨质疏松/中医药疗法 @强骨胶囊 

分 类 号：R681[医药卫生—骨科学] R683.302[医药卫生—外科学]