奥拉西坦对急性轻型脑伤患者功能的影响  

Effect of Oxiracetam on acute mild head injuries

作　　者：但炜[1] 孙晓川[1] 刘福英[1] 唐文渊[1] 

机构地区：[1]重庆医科大学附属一院神经外科,重庆400016

出　　处：《创伤外科杂志》2006年第3期260-262,共3页Journal of Traumatic Surgery

摘　　要：目的 探讨奥拉西坦对急性轻型脑伤患者脑功能的影响，并对其进行Ⅲ期临床试验研究。方法 选择受伤后24小时入院的48例急性轻型脑伤（GCS 12～15分），随机双盲分别使用奥拉西坦及吡拉西坦进行治疗（均为4g＋250ml生理盐水静脉滴注，1次／d，连续使用21天）。定量脑电图监测用药前及用药后α、θ相对功率值及θ／α比值的变化。结果 用药后，奥拉西坦及吡拉西坦组α相对功率值均提高，而0相对功率值降低，且二者问比值缩小，有显著性差异。奥拉西坦组与吡拉西坦组比较，奥拉西坦作用更强，其差异更显著。结论 奥拉西坦能显著改善急性轻型脑伤患者的脑功能，其作用强于吡拉西坦。Objective To reveal the effect of Oxiracetam on acute mild head injuries, as tested by clinical study. Methods Forty-eight cases of acute mild head injuries （ GCS12 - 15 ,hospitalized within 24 hours after injury） were included in the study, all of them were treated with Oxiracetam or Pivecetam respectively （4mg ＋ 250ml/ d,for 21 day）. An electroencephalogram （EEG） was performed before and 21d after the treatment,the alpha-and theta-relative power and θ/α were analysed. Results The results showed that there was an significant increase of the alpha-relative power, and a significant decrease of the theta-relative power θ/α in the both groups, particularly in the group of Oxiracetam. Conchusion Oxiracetam was effective to improve brain function of patients with acute mild head injuries,its effect is better than that of Pivecetam.

关 键 词：颅脑损伤 定量脑电图 奥拉西坦 吡拉西坦 

分 类 号：R651.15[医药卫生—外科学]