红景天对高原去势大鼠骨质疏松症的血清IL-6、TNF-α和尿DPD影响  

Effect of CO-RADIOD(RACC) on the contents of IL-6 and TNF-α in the serum and DPD in the urine of ovariectomized rats with osteoporosis at high altitude

作　　者：白孟海[1] 葛宝丰[1] 刘剑梅[1] 王琦[1] 高文魁[2] 郑荣[1] 

机构地区：[1]兰州军区兰州总医院骨科研究所,甘肃兰州730050 [2]西宁市解放军第四医院

出　　处：《中国骨伤》2006年第4期221-222,共2页China Journal of Orthopaedics and Traumatology

基　　金：全军科研基金课题(编号:01Z008)

摘　　要：目的:探讨高原高寒地区低氧环境去势大鼠骨质疏松症与血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和尿脱氧吡啶酚(DPD)的关系及红景天预防骨质疏松的作用。方法:选用Wistar雌性大白鼠75只,分别摘除卵巢或假性去卵巢。分为A组(假手术组),B组(切除卵巢组),C组(切除卵巢+尼尔雌醇组),D组(切除卵巢+红景天混合饲料组),E组(切除卵巢+红景天浸液组)。每组15只,术后在海拔3100m青海海北州地区饲养,术后3个月处死,应用放免方法测定血清IL-6、TNF-α和化学发光法测定尿中DPD含量。结果:B组血清IL-6、TNF-α和尿DPD含量显著高于A、C、D、E组。C、D、E组血清IL-6、TNF-α和尿DPD含量与A组比较差异无显著性统计学意义。结论:红景天的抗高原骨质疏松症的作用可能与降低血清IL-6、TNF-α含量和尿中DPD浓度有关。Objective： To discuss the relationship between ovariectomized rats with osteoporosis and IL-6,TNF-α in the serum and DPD in the urine at high altitude and the preventive effects of RACC on osteoporosis. Methods： Seventy-five ovariectomized Wistar female rats were divided into group A （ sham operation group）, group B （ ovariectomized group）, group C （ ovariectomized ＋ nilestriol）, group D （ ovariectomized ＋ mixed feed of RACC）,group E（ovariectomized ＋ RACC immersion）. The contents of IL-6,TNF-a in the serum and DPD in the urine were measured after 3 months of feed in Haibei district of Qinghai（3 100 m above sea level）. Results：The contents of IL-6,TNF-a in the serum and DPD in the urine in group B were significantly bighter than those of the group A,C,D and E;the contents of IL-6,TNF-a in the serum and DPD in the urine in the group C,D and E had no significant difference compared with gruop A. Conclusion：The preventive effect of RACC on osteoporosis may relate to the decrease of contents of IL-6,TNF-a in the serum and DPD in the urine.

关 键 词：骨质疏松 绝经后 动物 实验 白细胞介素-6 肿瘤坏死因子-Α 尿脱氧吡啶酚 

分 类 号：R587.1[医药卫生—内分泌] R446.6[医药卫生—内科学]