合成4-羟基香豆素最优条件的选择  

STUDY ON OPTIMAL CONDITION IN SYNTHESIS OF 4-HYDROXYCOUMARINS

作　　者：包小妹[1] 罗素琴[1] 刘乐乐[1] 张翠荣[1] 蒋洪[1] 白秀珍[2] 包懿[1] 

机构地区：[1]内蒙古医学院药学院,内蒙古呼和浩特010059 [2]内蒙古医学院基础医学院

出　　处：《内蒙古医学院学报》2006年第1期19-21,共3页Acta Academiae Medicinae Neimongol

摘　　要：目的:4-羟基香豆素是合成其他4-羟基香豆素衍生物的关键中间体,本研究摸索出了合成4-羟基香豆素的最有效条件。方法:以丙二酸和对甲酚为原料合成目标化合物,用正交试验摸索最优条件。结果与结论:筛选出的条件合成产率有显著提高,重复实验证明该条件是正确的。Objective： 4-hydroxycoumarin is a pivotal intermediate in synthesis of other 4-hydroxycoumarin derivatives. This article aims to investigate the optimal condition in synthesis of 4-hydroxycoumarin. Methods： The title compounds were synthesized from malonate and p-cresol. Orthogonal test was carried out to find out the optimal condition. Results and conclusion： The productivity under the optimal condition was improved significatly. Repeated tests showed that the optimal condition, which was found out, is perfect.

关 键 词：香豆素 正交试验 合成 

分 类 号：R284.3[医药卫生—中药学]