加用快速洋地黄类药物对发生在机械通气时新生儿肺出血的影响  

THE EFFECT OF QUICK DIGITALIS ON THE PULMONARY HEMORRHAGE IN THE NEWBORN INFANTS DURING MECHANICAL VENTILATION.

作　　者：严越秀[1] 莫伟雄[1] 张小玲[1] 汤鸣[1] 乔萍[1] 汪江萍[1] 

机构地区：[1]广东省肇庆市第一人民医院新生儿科,肇庆526021

出　　处：《现代预防医学》2006年第5期845-847,共3页Modern Preventive Medicine

摘　　要：目的:探索机械通气时引起新儿生肺出血的危险因素并早期加用快速洋地黄类药物对其治疗的有效手段。方法:采用临床试验方法,治疗组以机械通气加用快速洋地黄类药物:对照组以机械通气加用气管内滴入肾上腺素。分析病史资料、临床表现和治疗情况,对可能的危险因素、治疗效果进行统计学比较。结果:引起机械通气时出现肺出血的主要病因是重度窒息和胎粪吸入(共55.55%),合并酸中毒者21例(58.33%);与机械通气时呼吸机参数有一定的相关性。治疗组与对照组的临床资料具有可比性(P>0.05);两组在治疗后,肺出血停止时间分别为(2.15±1.35)h和(16.24±3.64)h(P<0.05);机械通气时间分别为(49.16±20.15)h和(72.53±22.45)h(P<0.05);治愈率分别为84.21%和52.94%(P>0.05);结论:机械通气时发生新生儿肺出血时早期加用快速洋地黄类药物,能有效快捷地控制肺出血,缩短机械通气时间,提高治愈率。Objective： To explore the effect of quick digitalis on the pulmonary hemorrhage in the new.born infants during mechanical ventilation. Methods： From January 1998 to January 2005, 36 cases newborns with pulmonary hemorrhage were observed during mechanical ventiation, 19 cases in treatment group and 17 cases in control group. The patients in treatment group were treated with mechanical ventilation combined with quick digitalis, mechanical ventiation combined with adrenaline injection in the control group. The clinical history, clinical symptoms and treatment patients were compared, the statistical analysis was performed. Re. suits： The major cause of pulmonary hemorrhage during mechanical ventilation were severe asphyxia and meconium aspiration （55. 55% ）, 21 patients combined with acidosis （58. 33% ）, it had certain correlation with the respirator parameters. The clinical data were comparable between two groups （P 〉 0.05）. Alter being treated, the stopping time of pulmonary hemorrhage in treatment group and control group was 2. 15 ± 1. 35 h and 16. 24±3. 64 h （P〈0.05） ; The mechanical ventiation time was 49. 16 ± 20. 15 hand72. 53±22. 45 h （P〈0.05）; The eure ratewas84. 21% and 52. 94% （P〈0.05）. Conclusion： The early usage of quick digitalis can effectively and quickly control pulmonary hemorrhage of newborn infants during mechanical ventilation as well as reduce the time of mechanical ventilation and improve the cure rate.

关 键 词：婴儿 新生 出血 肺性 机械通气 洋地黄类 

分 类 号：R722.15[医药卫生—儿科]