含甲肝病毒基因的重组痘苗病毒在动物体内产生针对甲肝病毒的中和抗体  

INDUTION OF HEPATITIS A VIRUS NEUTRALZIING ANTIBODY IN RABBITS IMMUNIZED WITH RECOMBINANT VACCINIA VIRUS

作　　者：高峰[1] 伊瑶[1] 赵洪兰[1] 刘崇柏[1] 

机构地区：[1]中国预防医学科学院病毒学研究所

出　　处：《病毒学报》1990年第3期216-218,共3页Chinese Journal of Virology

摘　　要：用DNA重组技术得到的含甲肝病毒基因的重组痘苗病毒,可在家兔体内产生ELISA竞争抑制与中和抗体。基础免疫后,动物体内竞争抑制抗体滴度为10,加强免疫后达到80。由重组病毒产生的抗体中和指数比甲肝病毒产生者略低。Recombinant vaccinia virus containing hepatitis A virus gene could induce ELISA competition inhibition and neutralizing antibodies in rabbits. After primary immunization, the ELISA antibody titer was about 1 : 10. But after boost, the antibody titer rose to 1 :80. The neutralizing index of the antibody induced by recombinant viccinia virus was slightly lower than that induced by HAAg.

关 键 词：甲型肝炎病毒 重组痘苗病毒 抗体 

分 类 号：R373.21[医药卫生—病原生物学]