B淋巴细胞刺激因子及其拮抗剂与系统性红斑狼疮  

The role of B lymphocyte stimulator and its antagonists in systemic lupus erythematosus

作　　者：苏虹[1] 叶冬青（审校）[2] 

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学系,230032合肥 [2]安徽医科大学研究生学院

出　　处：《国际免疫学杂志》2006年第3期184-188,共5页International Journal of Immunology

基　　金：国家自然科学基金资助项目(30371247)

摘　　要：B淋巴细胞刺激因子是B细胞生长、发育和分化中重要的免疫调控因子,其过度表达可能参与系统性红斑狼疮(systemiclupuserythematosus,SLE)发病机制中自身反应性B细胞的产生和自身免疫耐受的失衡。鉴于BlyS具有明显的B细胞趋向性,针对BLyS靶目标研制特异性抗体、相应受体或人可溶性BLyS结合小肽等,通过特异性封闭BLyS的免疫调控信号,拮抗其诱导的T、B淋巴细胞的高度活化和病理性自身抗体的产生,有望开辟一条治疗SLE等自身免疫病的新途径。B lymphocyte stimulator（BLys） is an immune regulatory factor for growth, development and differentiation of B lymphocyte. Overexpression of BLys may participate in the pathogenesis involved in systemic lupus erythematosus（SLE） for the generation of autoreactive B cell and disequilibrium of autoimmune tolerance. Owing to the conspicuous tropism of BlyS targeting B cell, the specific antibodies, corresponding receptors or small peptides binding to human soluble BLyS can be directly produced targeting at BLyS. Therefore, the immunoregulatory signal induced by BLys can be blocked and the overactivation of T and B lymphocytes and the production of autoantibody can be antagonized. Thus it may open up the new treatment for the autoimmune disease such as SLE.

关 键 词：B淋巴细胞刺激因子 生物学治疗 拮抗剂 系统性红斑狼疮 发病机制 

分 类 号：R593.241[医药卫生—内科学]